Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Di(Hydroxyethyl)Ether SCHEMBL8621256 | 1.00 | TSHR (0.67) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL28090651 | 1.00 | TSHR (0.67) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL854457 | 0.97 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL1573538 | 0.97 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Phosphoric Acid SCHEMBL899139 | 0.97 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL874011 | 0.97 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Tetraethylene Glycol SCHEMBL236335 | 0.97 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Hexaethylene Glycol SCHEMBL875412 | 0.97 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL816783 | 0.97 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Pentaethylene Glycol SCHEMBL1627452 | 0.97 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023095841-A1 | METHOD FOR EVALUATING DNA-ENCODED LIBRARY | 日産化学株式会社 | 2023-06-01 | — | — | WO | claimed |
| CN-115461456-A | Cleavable DNA-encoded libraries | 日产化学株式会社 | 2022-12-09 | — | — | CN | claimed |
| WO-2021241528-A1 | CLEAVABLE DNA-ENCODED LIBRARY | 日産化学株式会社 | 2021-12-02 | — | — | WO | claimed |
| CN-109627430-B | Phosphorus-containing flame-retardant polyester and preparation method and application thereof | 中国石油化工股份有限公司 | 2021-07-13 | — | — | CN | claimed |
| CN-112759899-A | Flame-retardant high-heat-resistance resin composition and preparation method and application method thereof | 四川省金路树脂有限公司 | 2021-05-07 | — | — | CN | claimed |
| CN-109776780-B | Phosphorus-containing flame-retardant PTT and preparation method and application thereof | 中国石油化工股份有限公司 | 2021-04-06 | — | — | CN | claimed |
| CN-107988609-A | A kind of steel degreasing and rust removal descales cleaning agent | 苏州禾川化学技术服务有限公司 | 2018-05-04 | — | — | CN | claimed |
| CN-104530377-B | A kind of temperature controllable polyurethane material for car clothing and preparation method thereof | 黎明化工研究设计院有限责任公司 | 2018-03-16 | — | — | CN | claimed |
| EP-4714453-A1 | USE OF STRUCTURE FOR NUCLEIC ACID DELIVERY IN TREATMENT OF HEMATOPOIETIC TUMOR | Japan Science and Technology Agency (JP) | 2026-03-25 | — | — | EP | disclosed |
| CN-119613849-A | Low-smoke halogen-free material for B2ca high-flame-retardance high-flexibility cable and preparation method thereof | 中广核三角洲（江苏）塑化有限公司 | 2025-03-14 | — | — | CN | disclosed |
| WO-2024242065-A1 | USE OF STRUCTURE FOR NUCLEIC ACID DELIVERY IN TREATMENT OF HEMATOPOIETIC TUMOR | 国立研究開発法人科学技術振興機構 | 2024-11-28 | — | — | WO | disclosed |
| US-20240238325-A1 | Artificial Nucleic Acid and Method for Delivery of Nucleic Acid Using the Same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2024-07-18 | — | — | US | disclosed |
| CN-114391031-B | Aqueous dispersion of polymeric particles | 陶氏环球技术有限责任公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-114072477-B | Acrylic adhesive composition | 罗门哈斯公司 | 2024-04-16 | — | — | CN | disclosed |
| EP-2058346-A1 | RESIN COMPOSITION FOR OPTICAL MATERIAL AND OPTICAL MATERIAL USING THE SAME | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2009-05-13 | — | — | EP | disclosed |
| US-6558870-B1 | Superior in image reproducibility | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 2003-05-06 | — | — | US | disclosed |
| EP-1063100-A2 | Water-washable photosensitive flexographic printing plate | Toyo Boseki Kabushiki Kaisha (JP) | 2000-12-27 | — | — | EP | disclosed |
| EP-0514588-B1 | Novel phosphobetaine and detergent and cosmetic containing the same | KAO CORP (JP) | 1997-06-11 | — | — | EP | disclosed |
| US-5409705-A | Phosphobetaine and detergent and cosmetic containing the same | KAO CORPORATION (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0514588-A2 | Novel phosphobetaine and detergent and cosmetic containing the same | Kao Corporation (JP) | 1991-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240238325-A1 | Artificial Nucleic Acid and Method for Delivery of Nucleic Acid Using the Same | HNRNPH3, RNASEH1, HNRNPA1 | TSHR 1640/4885MAPK1 3438/4885MEN1 920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.