Pirodomast

Pirodomast

SCHEMBL125348

O=c1c(N2CCCC2)c(O)c2cccnc2n1-c1ccccc1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 1/20 0.52
ALDH1A1 P00352 3/20 0.49
KDM4E B2RXH2 2/20 0.49
PDE4A P27815 7/20 0.48
PDE4B Q07343 6/20 0.48
PDE4C Q08493 6/20 0.48
PDE4D Q08499 6/20 0.48
TSHR P16473 2/20 0.45
CYP2C19 P33261 2/20 0.45
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
LMNA P02545 1/20 0.44
PDE1A P54750 1/20 0.42
PDE1B Q01064 1/20 0.42
LOXL3 P58215 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
GAA P10253 1/20 0.42
CYP2D6 P10635 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pirodomast SCHEMBL29385413 1.00 FEN1 (0.52) FEN1ALDH1A1KDM4EPDE4APDE4B
Pirodomast SCHEMBL9488218 0.99 FEN1 (0.51) FEN1ALDH1A1KDM4EPDE4APDE4B
SCHEMBL9629983 0.99 FEN1 (0.51) FEN1ALDH1A1KDM4EPDE4APDE4B
Water SCHEMBL9629740 0.98 FEN1 (0.50) FEN1ALDH1A1KDM4EPDE4APDE4B
SCHEMBL9629745 0.88 FEN1 (0.48) FEN1ALDH1A1KDM4EPDE4APDE4B
Water SCHEMBL9629016 0.87 FEN1 (0.47) FEN1ALDH1A1KDM4EPDE4APDE4B
Pirodomast SCHEMBL607268 0.87 LOXL3 (0.43) FEN1ALDH1A1KDM4EPDE4APDE4B
Water SCHEMBL10427748 0.85 MAPT (0.44) FEN1ALDH1A1KDM4EPDE4BPDE4D
Water SCHEMBL10582943 0.85 FEN1 (0.46) FEN1ALDH1A1PDE4APDE4BPDE4C
SCHEMBL125349 0.82 FEN1 (0.49) FEN1ALDH1A1KDM4EPDE4APDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 365 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103664804-B Pirodomast analogue, preparation method and application thereof ANHUI UNIVERSITY OF CHINESE MEDICINE (CN) 2016-01-20 CN claimed
CN-102596202-B Crystalline forms of pemirolast CARDOZ AB 2015-01-21 CN claimed
CN-103987704-A Flavonoid compounds CARDERO THERAPEUTICS INC 2014-08-13 CN claimed
CN-103664804-A Picotamide analogues as well as preparation method and application thereof ANHUI UNIVERSITY OF CHINESE MEDICINE 2014-03-26 CN claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
CN-101711279-A Use of tp modulators for the treatment of cardiovascular disorders in aspirin sensitive and other populations PORTOLA PHARM INC 2010-05-19 CN claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
EP-0232328-B1 ZWITTERIONIC BICYCLIC COMPOUNDS AND THEIR SALTS, SOLVATES, HYDRATES AND ESTERS SCHERING CORPORATION (US) 1992-04-15 EP claimed
EP-0338010-B1 PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF HYPERPROLIFERATE SKIN DISEASE SCHERING CORPORATION (US) 1992-02-05 EP claimed
US-4684727-A Zwitterionic 1,8-naphthyridine and pyrazino[2,3-b]pyridine containing compounds useful as anti-allergic, anti-inflammatory and cycloprotective agents SCHERING CORPORATION (US) 1987-08-04 US claimed
EP-2841109-B1 PRODRUGS OF HYDROXYL-COMPRISING DRUGS ASCENDIS PHARMA AS (DK) 2026-04-15 EP disclosed
EP-4706683-A2 CHEWABLE FORMULATIONS Elanco Tiergesundheit AG (CH) 2026-03-11 EP disclosed
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES AQUESTIVE THERAPEUTICS, INC. (US) 2026-02-05 US disclosed
US-5079360-A Processes for preparing bicyclic compounds and intermediates thereof SCHERING CORPORATION (US) 1992-01-07 US disclosed
US-4897487-A Process for preparing intermediates for pharmaceutically useful bicyclic compounds SCHERING CORPORATION (US) 1990-01-30 US disclosed
EP-0302303-A2 Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation SCHERING CORPORATION (US) 1989-02-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES SORD, SLC6A13, CACNA1A FEN1 4024/4885ALDH1A1 683/4885KDM4E 1515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.