Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 3/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | PRKACG | P22612 | 1/20 | 0.48 |
| ▸ | PRKACB | P22694 | 1/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16516393 | 0.85 | KDM4E (0.63) | FLT3CDK2SMN1; SMN2PRKACAPRKACG | |
| SCHEMBL14542625 | 0.85 | YTHDC1 (0.56) | YTHDC1FLT3CDK2PAK1SMN1; SMN2 | |
| SCHEMBL12582647 | 0.85 | SMN1; SMN2 (0.59) | FLT3CDK2SMN1; SMN2PRKACAPRKACG | |
| SCHEMBL176882 | 0.84 | PRKAG1 (0.66) | FLT3CDK2SMN1; SMN2PRKAG1PRKAA1 | |
| SCHEMBL18554248 | 0.84 | BCHE (0.56) | FLT3CDK2SMN1; SMN2PRKACAPRKACG | |
| SCHEMBL13069602 | 0.82 | JAK2 (0.51) | FLT3CDK2SMN1; SMN2JAK2JAK1 | |
| SCHEMBL4012655 | 0.80 | PRKAG1 (0.48) | FLT3CDK2SMN1; SMN2PRKACAPRKACG | |
| SCHEMBL3953836 | 0.80 | FLT3 (0.49) | FLT3CDK2SMN1; SMN2PRKACAPRKACG | |
| SCHEMBL12582658 | 0.80 | GSK3B (0.70) | CDK2GSK3B | |
| SCHEMBL29871192 | 0.79 | IDO1 (0.64) | YTHDC1FLT3CDK2PAK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336128-A1 | Benzoisothiazoles and preparation and uses thereof | Memory Pharmaceuticals Corporation (US) | 2011-06-22 | — | — | EP | disclosed |