Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 12/20 | 0.47 |
| ▸ | THRA | P10827 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | PPARG | P37231 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 3/20 | 0.47 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13949735 | 0.90 | THRB (0.41) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL17612147 | 0.84 | THRB (0.42) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL12584474 | 0.83 | THRB (0.62) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL8189234 | 0.82 | THRB (0.44) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL18556479 | 0.82 | THRB (0.58) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL1526086 | 0.79 | THRB (0.44) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL12584488 | 0.79 | THRB (0.47) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL13949736 | 0.78 | THRB (0.64) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL19308104 | 0.77 | THRB (0.45) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL1526072 | 0.77 | THRB (0.61) | THRBTHRAMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9750709-B2 | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof | NANOPHARMACEUTICALS LLC (US) | 2017-09-05 | — | — | US | disclosed |
| US-9579300-B2 | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof | NANOPHARMACEUTICALS LLC (US) | 2017-02-28 | — | — | US | disclosed |
| US-9289395-B2 | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof | NANOPHARMACEUTICALS LLC (US) | 2016-03-22 | — | — | US | disclosed |
| US-20140314665-A1 | NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE ANALOGS, ANTAGONISTS, AND FORMULATIONS THEREOF | NANOPHARMACEUTICALS LLC (US) | 2014-10-23 | — | — | US | disclosed |
| US-8668926-B1 | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof | NANOPHARMACEUTICALS LLC | 2014-03-11 | — | — | US | disclosed |
| US-20110142941-A1 | Nanoparticle and Polymer Formulations for Thyroid Hormone Analogs, Antagonists, and Formulations and Uses Thereof | NANOPHARMACEUTICALS LLC | 2011-06-16 | — | — | US | disclosed |
| US-20090022806-A1 | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists and formulations and uses thereof | ORDWAY RESEARCH INSTITUTE, INC. | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140314665-A1 | NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE ANALOGS, ANTAGONISTS, AND FORMULATIONS THEREOF | TSHR, TRHR, THRA | THRB 4/4885THRA 3/4885MEN1 422/4885 |
| US-20090022806-A1 | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists and formulations and uses thereof | TSHR, THRA, TRHR | THRB 4/4885THRA 2/4885MEN1 505/4885 |
| US-20110142941-A1 | Nanoparticle and Polymer Formulations for Thyroid Hormone Analogs, Antagonists, and Formulations and Uses Thereof | TSHR, THRA, TRHR | THRB 4/4885THRA 2/4885MEN1 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.