Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 2/20 | 0.50 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL813771 | 0.87 | CYP1A2 (0.50) | TAAR1HTR2ACYP1A2CYP2D6PKM | |
| SCHEMBL12824731 | 0.84 | ALDH1A1 (0.53) | GABBR2GABBR1TAAR1HTR2ACYP1A2 | |
| SCHEMBL9246055 | 0.83 | CYP1A2 (0.42) | HTR2ACYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL1169267 | 0.83 | CYP1A2 (0.42) | HTR2ACYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL4476581 | 0.81 | LMNA (0.45) | TAAR1HTR2ACYP1A2CYP2D6PKM | |
| SCHEMBL12819487 | 0.81 | LMNA (0.45) | TAAR1HTR2ACYP1A2CYP2D6PKM | |
| SCHEMBL11992984 | 0.81 | LMNA (0.45) | TAAR1HTR2ACYP1A2CYP2D6PKM | |
| SCHEMBL14453825 | 0.80 | TAAR1 (0.50) | GABBR2GABBR1TAAR1HTR2ACYP1A2 | |
| SCHEMBL14791784 | 0.80 | GABBR2 (0.47) | GABBR2GABBR1TAAR1HTR2ACYP1A2 | |
| SCHEMBL1539105 | 0.79 | TAAR1 (0.65) | GABBR2GABBR1TAAR1HTR2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590666-A4 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH INC (US) | 2006-07-26 | — | — | EP | claimed |
| EP-1590666-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | Genentech, Inc. (US) | 2005-11-02 | — | — | EP | claimed |
| WO-2004072641-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH, INC. (US) | 2004-08-26 | — | — | WO | claimed |
| US-9346805-B2 | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20110039324-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH, INC. (US) | 2011-02-17 | — | — | US | disclosed |
| WO-2003014113-A1 | NOVEL BENZOPYRAN COMPOUNDS AND PROCESS FOR THEIR PREPARATION AND USE | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2003-02-20 | — | — | WO | disclosed |