Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 8/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.63 |
| ▸ | MITF | O75030 | 1/20 | 0.63 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | CKS1B | P61024 | 1/20 | 0.63 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | GLO1 | Q04760 | 7/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | G6PD | P11413 | 1/20 | 0.57 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30925435 | 0.85 | SLC40A1 (0.74) | SLC40A1TDP1KMT2AAGTR1MITF | |
| SCHEMBL16750883 | 0.85 | SLC40A1 (0.74) | SLC40A1TDP1KMT2AAGTR1MITF | |
| SCHEMBL13485919 | 0.81 | GLO1 (0.80) | SLC40A1TDP1KMT2AAGTR1MITF | |
| SCHEMBL30925457 | 0.79 | SLC40A1 (0.59) | SLC40A1TDP1KMT2AAGTR1MITF | |
| SCHEMBL27214288 | 0.79 | SLC40A1 (0.59) | SLC40A1TDP1KMT2AAGTR1MITF | |
| SCHEMBL11973852 | 0.78 | SLC40A1 (1.00) | SLC40A1TDP1KMT2AAGTR1MITF | |
| SCHEMBL4471796 | 0.78 | TDP1 (1.00) | SLC40A1TDP1KMT2AAGTR1MITF | |
| SCHEMBL12598513 | 0.78 | SMN1; SMN2 (0.59) | KMT2AALDH1A1LMNAMEN1SMN1; SMN2 | |
| SCHEMBL30925437 | 0.77 | SLC40A1 (0.74) | SLC40A1TDP1KMT2AAGTR1MITF | |
| SCHEMBL27214241 | 0.77 | SLC40A1 (0.74) | SLC40A1TDP1KMT2AAGTR1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072174-A1 | THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION | AGIOS PHARMACEUTICALS, INC. (US) | 2011-06-16 | — | — | WO | disclosed |