Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367682 | 0.78 | NR3C1 (0.64) | SMN1; SMN2NR3C1PGRNR3C2AR | |
| SCHEMBL12598516 | 0.78 | SLC40A1 (0.64) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1984869 | 0.76 | CA1 (0.60) | NR3C1PGRNR3C2ARMEN1 | |
| SCHEMBL1987233 | 0.75 | GFER (0.61) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL3061760 | 0.75 | NR3C1 (0.56) | NR3C1PGRNR3C2ARHSD17B10 | |
| SCHEMBL3055215 | 0.74 | NR3C1 (0.56) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL2367383 | 0.74 | NR3C1 (0.65) | SMN1; SMN2NR3C1PGRNR3C2AR | |
| SCHEMBL3066019 | 0.73 | SLC40A1 (0.57) | NR3C1PGRNR3C2ARPTGES2 | |
| SCHEMBL2367735 | 0.73 | NR3C1 (0.60) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL2403697 | 0.72 | TUBB4A (0.61) | NR3C1PGRNR3C2ARLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072174-A1 | THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION | AGIOS PHARMACEUTICALS, INC. (US) | 2011-06-16 | — | — | WO | disclosed |