Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.33 |
| ▸ | IDO1 | P14902 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29424779 | 0.79 | GABRA1 (0.56) | GABRA1GABRB2TSHRPOLBCA2 | |
| SCHEMBL30369671 | 0.79 | GABRA1 (0.56) | GABRA1GABRB2TSHRPOLBCA2 | |
| SCHEMBL4681487 | 0.79 | GABRA1 (0.56) | GABRA1GABRB2TSHRPOLBCA2 | |
| SCHEMBL3833921 | 0.79 | GABRA1 (0.56) | GABRA1GABRB2TSHRPOLBCA2 | |
| SCHEMBL15670229 | 0.79 | GABRA1 (0.56) | GABRA1GABRB2TSHRPOLBCA2 | |
| SCHEMBL25415814 | 0.79 | GABRA1 (0.56) | GABRA1GABRB2TSHRPOLBCA2 | |
| SCHEMBL20631317 | 0.78 | CA1 (0.53) | GABRA1GABRB2TSHRPOLBCA2 | |
| SCHEMBL20630752 | 0.78 | CA1 (0.53) | GABRA1GABRB2TSHRPOLBCA2 | |
| SCHEMBL24017155 | 0.74 | ALDH1A1 (0.46) | LMNAALDH1A1CYP2C19 | |
| SCHEMBL24017011 | 0.73 | IDO1 (0.37) | IDO1ALOX15ALDH1A1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146986-B1 | DIPHENYL-DIHYDRO-IMIDAZOPYRIDINONES | HOFFMANN LA ROCHE (CH) | 2011-06-29 | — | — | EP | disclosed |