Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25415814 | 1.00 | GABRA1 (0.56) | GABRA1GABRB2TSHRALDH1A1ALOX15 | |
| SCHEMBL4681487 | 1.00 | GABRA1 (0.56) | GABRA1GABRB2TSHRALDH1A1ALOX15 | |
| SCHEMBL3833921 | 1.00 | GABRA1 (0.56) | GABRA1GABRB2TSHRALDH1A1ALOX15 | |
| SCHEMBL30369671 | 1.00 | GABRA1 (0.56) | GABRA1GABRB2TSHRALDH1A1ALOX15 | |
| SCHEMBL29424779 | 1.00 | GABRA1 (0.56) | GABRA1GABRB2TSHRALDH1A1ALOX15 | |
| SCHEMBL18650079 | 0.83 | GABRA1 (0.56) | GABRA1GABRB2TSHRALDH1A1ALOX15 | |
| SCHEMBL3949185 | 0.83 | GABRA1 (0.56) | GABRA1GABRB2TSHRALDH1A1ALOX15 | |
| SCHEMBL29395043 | 0.83 | GABRA1 (0.56) | GABRA1GABRB2TSHRALDH1A1ALOX15 | |
| SCHEMBL640127 | 0.81 | GABRA1 (0.54) | GABRA1GABRB2TSHRALDH1A1ALOX15 | |
| SCHEMBL5597399 | 0.80 | GABRA1 (0.43) | GABRA1GABRB2TSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760750-B1 | Process for preparing levoketoconazole | NURAY CHEMICALS PRIVATE LIMITED (IN) | 2023-09-19 | — | — | US | claimed |
| US-11760750-B1 | Process for preparing levoketoconazole | NURAY CHEMICALS PRIVATE LIMITED (IN) | 2023-09-19 | — | — | US | disclosed |
| WO-2023099623-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-06-08 | — | — | WO | disclosed |
| WO-2023099623-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-06-08 | — | — | WO | disclosed |
| US-10392353-B2 | Processes for making substituted quinazoline compounds using hydrogen bonding catalysts | MERCK SHARP & DOHME CORP. (US) | 2019-08-27 | — | — | US | disclosed |
| US-10392353-B2 | Processes for making substituted quinazoline compounds using hydrogen bonding catalysts | MERCK SHARP & DOHME CORP. (US) | 2019-08-27 | — | — | US | disclosed |
| US-20180346429-A1 | NOVEL PROCESSES FOR MAKING SUBSTITUTED QUINAZOLINE COMPOUNDS USING HYDROGEN BONDING CATALYSTS | MERCK SHARP & DOHME CORP. (US) | 2018-12-06 | — | — | US | disclosed |
| US-20180093992-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME LLC | 2018-04-05 | — | — | US | disclosed |
| US-20180093992-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME LLC | 2018-04-05 | — | — | US | disclosed |
| US-9862725-B2 | Process for preparing chiral dipeptidyl peptidase-IV inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-01-09 | — | — | US | disclosed |
| US-9701684-B2 | Chiral fluorinating reagents | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2017-07-11 | — | — | US | disclosed |
| US-20170158701-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME LLC | 2017-06-08 | — | — | US | disclosed |
| US-20170158701-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME LLC | 2017-06-08 | — | — | US | disclosed |
| WO-2017091453-A1 | NOVEL PROCESSES FOR MAKING SUBSTITUTED QUINAZOLINE COMPOUNDS USING HYDROGEN BONDING CATALYSTS | MERCK SHARP & DOHME CORP. (US) | 2017-06-01 | — | — | WO | disclosed |
| WO-2016014324-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-01-28 | — | — | WO | disclosed |
| US-20150284401-A1 | CHIRAL FLUORINATING REAGENTS | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2015-10-08 | — | — | US | disclosed |
| EP-2914582-A2 | CHIRAL FLUORINATING REAGENTS | Isis Innovation Limited (GB) | 2015-09-09 | — | — | EP | disclosed |
| WO-2014068341-A2 | CHIRAL FLUORINATING REAGENTS | ISIS INNOVATION LIMITED (GB) | 2014-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284401-A1 | CHIRAL FLUORINATING REAGENTS | TIAM1, AFF2, AFF1 | GABRA1 1083/4885GABRB2 1412/4885TSHR 1267/4885 |
| US-20180093992-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | DPP4, PEPD, DPP9 | GABRA1 3000/4885GABRB2 2341/4885TSHR 2099/4885 |
| US-20170158701-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | DPP4, PEPD, DPP9 | GABRA1 3026/4885GABRB2 2372/4885TSHR 2106/4885 |
| US-10392353-B2 | Processes for making substituted quinazoline compounds using hydrogen bonding catalysts | NQO1, NDUFS7, NDUFS2 | GABRA1 3388/4885GABRB2 3247/4885TSHR 4787/4885 |
| US-20180346429-A1 | NOVEL PROCESSES FOR MAKING SUBSTITUTED QUINAZOLINE COMPOUNDS USING HYDROGEN BONDING CATALYSTS | NQO1, NDUFS3, SDHA | GABRA1 3789/4885GABRB2 3532/4885TSHR 4833/4885 |
| US-11760750-B1 | Process for preparing levoketoconazole | KHK, KYAT3, PLK3 | GABRA1 2143/4885GABRB2 2414/4885TSHR 2394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.