Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859058 | 0.92 | MAPT (0.44) | HTR6ABL1AOC3LMNASMN1; SMN2 | |
| SCHEMBL10117308 | 0.77 | TNIK (0.44) | ABL1SMN1; SMN2RAB9ABACE1PTGES | |
| SCHEMBL20169736 | 0.76 | SCN9A (0.61) | AOC3SMN1; SMN2HTTL3MBTL1MEN1 | |
| SCHEMBL14576669 | 0.76 | TGFBR1 (0.47) | HTR6LMNARAB9AKDM4EGAA | |
| SCHEMBL31678858 | 0.74 | HTR6 (0.43) | HTR6ABL1LMNASMN1; SMN2MEN1 | |
| SCHEMBL10117301 | 0.73 | MAPT (0.44) | ABL1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL19501569 | 0.71 | NPC1 (0.52) | MEN1KMT2ARAB9ANPC1BACE1 | |
| SCHEMBL20268646 | 0.71 | KDM4E (0.40) | HTR6LMNAL3MBTL1POLBKDM4E | |
| SCHEMBL2163044 | 0.71 | CCNB2 (0.44) | L3MBTL1MEN1POLBKMT2ARAB9A | |
| SCHEMBL10117305 | 0.71 | TUBB4A (0.42) | ABL1LMNASMN1; SMN2MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA' DEGLISTUDI DI MILANO- BICOCCA (IT) | 2011-05-12 | — | — | US | disclosed |
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA' DEGLISTUDI DI MILANO- BICOCCA (IT) | 2011-05-12 | — | — | US | disclosed |
| WO-2009121535-A2 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA`DEGLI STUDI DI MILANO - BICOCCA (IT) | 2009-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | ABL1, MKI67, BCR | HTR6 3931/4885ABL1 1/4885AOC3 4413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.