SCHEMBL1260282

SCHEMBL1260282

Cn1cnc2nc(N)nc(S)c21

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 3/20 0.34
CCNB1 P14635 1/20 0.34
CCNE1 P24864 1/20 0.34
CDK2 P24941 1/20 0.34
HRH4 Q9H3N8 1/20 0.33
ADORA2A P29274 4/20 0.32
ADORA1 P30542 3/20 0.32
PIK3CD O00329 1/20 0.30
POLB P06746 1/20 0.30
ADORA3 P0DMS8 1/20 0.30
CNR1 P21554 1/20 0.30
ACHE P22303 1/20 0.30
ADORA2B P29275 1/20 0.30
NTSR1 P30989 1/20 0.30
MC3R P41968 1/20 0.30
NOTUM Q6P988 1/20 0.30
SIRT3 Q9NTG7 1/20 0.30
GDA Q9Y2T3 1/20 0.30
NR2E1 Q9Y466 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29551511 1.00 CDK1 (0.34) CDK1CCNB1CCNE1CDK2HRH4
SCHEMBL2775208 0.81 GDA (0.32) ADORA2AADORA1PIK3CDPOLBADORA3
SCHEMBL12311046 0.78 ADORA2A (0.46) CDK1CCNB1CCNE1CDK2HRH4
SCHEMBL7617554 0.78 CDK1 (0.37) CDK1CCNB1CCNE1CDK2HRH4
Xylose SCHEMBL25306145 0.78 AHCY (0.30)
SCHEMBL12261690 0.74 CDK1 (0.35) CDK1ADORA2AADORA1PIK3CDPOLB
SCHEMBL17226007 0.70 CDK1 (0.55) CDK1CCNB1CCNE1CDK2ADORA2A
SCHEMBL9466617 0.67 ADORA2A (0.38) ADORA2AADORA1PIK3CDPOLBADORA3
SCHEMBL12283253 0.67 CDK1 (0.35) CDK1CCNB1CCNE1CDK2ADORA2A
SCHEMBL11556607 0.67 CDK1 (0.54) CDK1ADORA2AADORA1PIK3CDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 227 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3516077-A1 METHODS AND COMPOSITIONS FOR DETECTING ANALYTES Alveo Technologies Inc. (US) 2019-07-31 EP claimed
WO-2018057647-A1 METHODS AND COMPOSITIONS FOR DETECTING ANALYTES ALVEO TECHNOLOGIES, INC. (US) 2018-03-29 WO claimed
US-12565661-B2 Compositions and methods for weed control SYNGENTA CROP PROTECTION AG (CH) 2026-03-03 US disclosed
US-20250375450-A1 SMARCA2/4 INHIBITION AS A STRATEGY TO TREAT TUMORS THAT HARBOR ABERRANT BAF ASSEMBLIES UNIV TEXAS (US) 2025-12-11 US disclosed
US-20250346938-A1 ATP-DEPENDENT C-TERMINAL MODIFICATION OF POLYPEPTIDES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2025-11-13 US disclosed
US-12435088-B2 Salicyl-adenosinemonosulfamate analogs and uses thereof MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2025-10-07 US disclosed
US-12331343-B2 FAMIN assay methods CAMBRIDGE ENTERPRISE LIMITED (GB) 2025-06-17 US disclosed
US-20250059187-A1 COVALENTLY BINDING INHIBITORS OF G12S, G12D AND/OR G12E MUTANTS OF K-RAS GTPASE UNIV CALIFORNIA (US) 2025-02-20 US disclosed
EP-4460294-A2 SMARCA2/4 INHIBITION AS A STRATEGY TO TREAT TUMORS THAT HARBOR ABERRANT BAF ASSEMBLIES Board of Regents, The University of Texas System (US) 2024-11-13 EP disclosed
EP-4452416-A1 COVALENTLY BINDING INHIBITORS OF G12S, G12D AND/OR G12E MUTANTS OF K-RAS GTPASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-10-30 EP disclosed
CN-118786129-A Covalent binding inhibitors of G12S, G D and/or G12E mutants of K-RAS GTPases 加利福尼亚大学董事会 2024-10-15 CN disclosed
WO-2002010358-A2 NUCLEOTIDE INCORPORATING ENZYMES MAXYGEN, INC. (US) 2002-02-07 WO disclosed
US-6221640-B1 Enterococcal aminoacyl-trna synthetase proteins, nucleic acids and strains comprising same CUBIST PHARMACEUTICALS, INC. 2001-04-24 US disclosed
WO-2001016357-A2 NOVEL TARGET FOR ANTIPARASITIC AGENTS AND INHIBITORS THEREOF K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) 2001-03-08 WO disclosed
US-6174713-B1 NUCLEIC ACID WHICH CODES FOR PORTION OF ENZYME WHICH HAS CATALYTIC OR BINDING FUNCTION; FOR SCREENING FUNGICIDES, ANTIBIOTICS, AND ENZYME INHIBITORS CUBIST PHARMACEUTICALS, INC. 2001-01-16 US disclosed
WO-2000036082-A2 NOVEL FUNGAL mRNA CAPPING ENZYMES, AND METHODS OF USING THE SAME QUESTCOR PHARMACEUTICALS, INC. (US) 2000-06-22 WO disclosed
EP-0715721-B1 PHOSPHATE ASSAY MEDICAL RES COUNCIL (GB) 1999-11-10 EP disclosed
US-5898069-A PHOSPHATE-BINDING PROTEIN CONTAINING (I) AN INORGANIC PHOSPHATE ION BINDING SITE AND (II) A DETECTABLE LABEL THAT PRODUCES A SIGNAL WHOSE AMPLITUDE CHANGES DETECTABLY UPON THE BINDING OF INORGANIC PHOSPHATE ION TO THE BINDING SITE MEDICAL RESEARCH COUNCIL (GB) 1999-04-27 US disclosed
EP-0715721-A1 PHOSPHATE ASSAY MEDICAL RESEARCH COUNCIL (GB) 1996-06-12 EP disclosed
WO-1995002825-A1 PHOSPHATE ASSAY MEDICAL RESEARCH COUNCIL (GB) 1995-01-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12565661-B2 Compositions and methods for weed control RNGTT, DDT, TYMP CDK1 1800/4885CCNB1 1060/4885CCNE1 593/4885
US-20250059187-A1 COVALENTLY BINDING INHIBITORS OF G12S, G12D AND/OR G12E MUTANTS OF K-RAS GTPASE KRAS, HRAS, NRAS CDK1 587/4885CCNB1 811/4885CCNE1 312/4885
US-12435088-B2 Salicyl-adenosinemonosulfamate analogs and uses thereof ADSL, SLC35B2, ADORA1 CDK1 2222/4885CCNB1 3004/4885CCNE1 3710/4885
US-20250375450-A1 SMARCA2/4 INHIBITION AS A STRATEGY TO TREAT TUMORS THAT HARBOR ABERRANT BAF ASSEMBLIES SMARCA4, SMARCE1, SMARCC1 CDK1 974/4885CCNB1 1248/4885CCNE1 677/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.