Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12605488 | 0.78 | ALOX12 (0.33) | CDK2ALDH1A1MTNR1AALOX12HTR1A | |
| SCHEMBL12605483 | 0.78 | ALDH1A1 (0.43) | ALDH1A1NPY5RMAPT | |
| SCHEMBL12605462 | 0.78 | MTNR1A (0.54) | ALDH1A1MTNR1ANQO2KDM4EMAPT | |
| SCHEMBL12605492 | 0.78 | CYP2D6 (0.51) | POLBALDH1A1NPY5RKDM4EHTT | |
| SCHEMBL12605447 | 0.74 | MAPK1 (0.44) | MAPK1CDK2MTNR1AGPR84SLC6A4 | |
| SCHEMBL12605470 | 0.74 | MAPK1 (0.44) | MAPK1CDK2GPR84HTR1ASLC6A4 | |
| SCHEMBL12605481 | 0.74 | MTNR1A (0.47) | MTNR1AGPR84 | |
| SCHEMBL12244242 | 0.73 | MAPK1 (0.50) | MAPK1CDC7MAP4K4PAK4CDK2 | |
| SCHEMBL12605484 | 0.73 | MTNR1A (0.38) | MAPK1ALDH1A1MTNR1AKDM4EHSD17B10 | |
| SCHEMBL12605482 | 0.73 | SPR (0.46) | MTNR1AMAPTHSD17B10HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7227020-B2 | Azaindoles | AVENTIS PHARMA LIMITED (GB) | 2007-06-05 | — | — | US | disclosed |