Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | CCND3 | P30281 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | CCND1 | P24385 | 1/20 | 0.55 |
| ▸ | CCND2 | P30279 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 4/20 | 0.51 |
| ▸ | STAT6 | P42226 | 4/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12615133 | 0.79 | SMN1; SMN2 (0.47) | — | |
| SCHEMBL29972048 | 0.77 | PLK4 (0.68) | SYKTP53MAPTMAPK1IGF1R | |
| SCHEMBL13061369 | 0.76 | MAPT (0.52) | TP53MAPTMAPK1 | |
| SCHEMBL19203865 | 0.75 | CCNK (0.67) | SYKCCND3LRRK2IGF1RCCNK | |
| SCHEMBL18757010 | 0.73 | JAK2 (0.58) | TP53MAPTMAPK1STAT6INSR | |
| SCHEMBL29777450 | 0.73 | SYK (0.60) | SYKCCND3CDK4CCND1CCND2 | |
| SCHEMBL7980595 | 0.73 | MAPT (0.62) | SYKTP53MAPTMAPK1PLK4 | |
| SCHEMBL23704665 | 0.72 | CCNK (0.65) | SYKCCND3TP53MAPTMAPK1 | |
| SCHEMBL27020249 | 0.72 | FLT3 (0.61) | SYKCCND3CDK4CCND1CCND2 | |
| SCHEMBL19203832 | 0.72 | FGFR1 (0.64) | SYKIGF1RSTAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688870-A1 | HETEROCYCLIC AMINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-01-29 | — | — | EP | disclosed |
| WO-2012126922-A1 | HETEROCYCLIC AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-27 | — | — | WO | disclosed |