Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.57 |
| ▸ | STAT6 | P42226 | 9/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | TTK | P33981 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12525667 | 0.83 | AOC3 (0.59) | — | |
| SCHEMBL12523890 | 0.80 | STAT6 (0.54) | JAK2NTRK1STAT6JAK1TTK | |
| SCHEMBL1038303 | 0.75 | PRMT6 (0.72) | NTRK1MAPT | |
| SCHEMBL18757112 | 0.74 | SIGMAR1 (0.45) | MAPK1 | |
| SCHEMBL30052705 | 0.74 | JAK2 (1.00) | JAK2JAK1JAK3PLK4 | |
| SCHEMBL2880284 | 0.74 | JAK2 (1.00) | JAK2JAK1JAK3PLK4 | |
| SCHEMBL12615134 | 0.73 | SYK (0.55) | STAT6INSRPLK4TP53MAPT | |
| SCHEMBL16530422 | 0.72 | INSR (0.68) | JAK2NTRK1STAT6JAK1TTK | |
| SCHEMBL18757044 | 0.72 | LTA4H (0.53) | TP53AURKB | |
| SCHEMBL13725016 | 0.72 | JAK2 (0.72) | JAK2JAK1JAK3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002278-B1 | GUANIDINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-04-19 | — | — | EP | disclosed |