Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR5 | P32302 | 6/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29803996 | 0.74 | NPC1 (0.33) | NPC1RAB9AALDH1A1LMNAHPGD | |
| SCHEMBL28737051 | 0.74 | OPRM1 (0.41) | SMN1; SMN2MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL28429879 | 0.73 | SLC6A3 (0.33) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL6252818 | 0.73 | BRD4 (0.40) | SMN1; SMN2MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL27593298 | 0.72 | OPRM1 (0.39) | SMN1; SMN2MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL28737053 | 0.72 | MEN1 (0.39) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL5581649 | 0.72 | SLC6A3 (0.35) | SMN1; SMN2L3MBTL1NPC1RAB9ACYP1A2 | |
| SCHEMBL6276886 | 0.71 | HSD11B1 (0.35) | MAPTNPC1RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL4619747 | 0.71 | HDAC4 (0.33) | SMN1; SMN2NPC1RAB9AHDAC4ALDH1A1 | |
| SCHEMBL10872336 | 0.71 | SRR (0.33) | MAPTL3MBTL1NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2685986-A2 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Genzyme Corporation (US) | 2014-01-22 | — | — | EP | disclosed |
| WO-2012129084-A2 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2012-09-27 | — | — | WO | disclosed |