Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 12/20 | 0.37 |
| ▸ | KDM5A | P29375 | 11/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 9/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2270385 | 0.80 | KDM4C (0.54) | KDM4CKDM5AKDM5BKDM2BPIK3CA | |
| SCHEMBL21004236 | 0.79 | LOXL2 (0.34) | KDM4CKDM5AKDM5BKDM2BPIK3CA | |
| SCHEMBL19608629 | 0.79 | CYP1A2 (0.47) | KDM4CKDM5AKDM5BKDM2BPIK3CA | |
| SCHEMBL2269172 | 0.78 | JMJD6 (0.54) | KDM4CKDM5AKDM5BPIK3CA | |
| SCHEMBL11983624 | 0.75 | CCR1 (0.52) | — | |
| SCHEMBL31329261 | 0.75 | CCR1 (0.52) | — | |
| SCHEMBL28767708 | 0.72 | LMNA (0.57) | LRRK2 | |
| SCHEMBL27716763 | 0.71 | LMNA (0.44) | — | |
| SCHEMBL14909322 | 0.71 | GRIN2D (0.46) | COMT | |
| SCHEMBL26663329 | 0.71 | ALDH1A1 (0.38) | COMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895484-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Genzyme Corporation (US) | 2015-07-22 | — | — | EP | claimed |
| WO-2014043068-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2014-03-20 | — | — | WO | claimed |
| EP-4098654-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Genzyme Corporation (US) | 2022-12-07 | — | — | EP | disclosed |
| EP-3534958-A1 | INHIBITORS OF GANGLIOSIDES METABOLISM FOR THE TREATMENT OF MOTOR NEURON DISEASES | ICM - Institut du Cerveau et da la Moelle Epinière (FR) | 2019-09-11 | — | — | EP | disclosed |
| EP-3377908-A1 | BIOMARKER OF POLYCYSTIC KIDNEY DISEASE AND USES THEREOF | Genzyme Corporation (US) | 2018-09-26 | — | — | EP | disclosed |
| EP-3177932-A2 | BIOMARKERS OF POLYCYSTIC KIDNEY DISEASE AND USES THEREOF | Genzyme Corporation (US) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016022500-A2 | BIOMARKERS OF POLYCYSTIC KIDNEY DISEASE AND USES THEREOF | GENZYME CORPORATION (US) | 2016-02-11 | — | — | WO | disclosed |
| EP-2895484-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Genzyme Corporation (US) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014043068-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2014-03-20 | — | — | WO | disclosed |
| EP-2685986-A2 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Genzyme Corporation (US) | 2014-01-22 | — | — | EP | disclosed |
| WO-2012129084-A2 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2012-09-27 | — | — | WO | disclosed |