SCHEMBL2270385

SCHEMBL2270385

O=C(O)c1ccnc(-n2cccc2)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 14/20 0.54
KDM5A P29375 12/20 0.54
KDM5B Q9UGL1 10/20 0.54
PIK3CA P42336 1/20 0.54
KDM2B Q8NHM5 5/20 0.53
KDM4A O75164 3/20 0.52
KDM4E B2RXH2 2/20 0.52
KDM6B O15054 2/20 0.52
KDM5C P41229 2/20 0.52
KDM2A Q9Y2K7 2/20 0.52
KDM3A Q9Y4C1 2/20 0.52
TET3 O43151 1/20 0.52
BBOX1 O75936 1/20 0.52
ALDH1A1 P00352 1/20 0.52
MAPT P10636 1/20 0.52
ASPH Q12797 1/20 0.52
KDM4D Q6B0I6 1/20 0.52
TET2 Q6N021 1/20 0.52
ALKBH5 Q6P6C2 1/20 0.52
KDM7A Q6ZMT4 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12169414 0.81 ADH5 (0.53) KDM4CKDM5AKDM5BPIK3CAKDM2B
SCHEMBL2269172 0.80 JMJD6 (0.54) KDM4CKDM5AKDM5BPIK3CAKDM4E
SCHEMBL12615420 0.80 KDM4C (0.37) KDM4CKDM5AKDM5BPIK3CAKDM2B
SCHEMBL28767708 0.80 LMNA (0.57) KDM4EALDH1A1MAPT
SCHEMBL31218872 0.79 KDM4C (0.54) KDM4CKDM5AKDM5BPIK3CAKDM2B
SCHEMBL15974174 0.78 LMNA (0.63) KDM4CKDM5AKDM5BPIK3CAKDM2B
SCHEMBL7827383 0.78 HTR2B (0.41)
SCHEMBL19608629 0.77 CYP1A2 (0.47) KDM4CKDM5AKDM5BPIK3CAKDM2B
SCHEMBL21004236 0.77 LOXL2 (0.34) KDM4CKDM5AKDM5BPIK3CAKDM2B
Hydrochloric Acid SCHEMBL7825427 0.77 HTR2B (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 KDM4C 1397/4885KDM5A 793/4885KDM5B 896/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.