Sugi Predict

Sugi Predict / Compounds / SCHEMBL126184

SCHEMBL126184

SCHEMBL126184

CC(C)(C)C(=O)Nc1ncc(F)cc1C=O

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 1/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ ABL1 P00519 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.34
▸ ERN1 O75460 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ ALOX12 P18054 1/20 0.34
▸ SIGMAR1 Q99720 7/20 0.34
▸ ADORA1 P30542 1/20 0.33
▸ MAP4K4 O95819 1/20 0.33
▸ KDR P35968 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ AGBL2 Q5U5Z8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5681020 0.85 HTT (0.38) L3MBTL1ALDH1A1ERN1LMNASIGMAR1
SCHEMBL29955740 0.84 SMN1; SMN2 (0.45) L3MBTL1ALDH1A1LMNAKDRGAA
SCHEMBL5677055 0.84 KDR (0.38) L3MBTL1ALDH1A1ERN1LMNASIGMAR1
SCHEMBL5218067 0.80 SYK (0.39) SYKL3MBTL1ABL1ALDH1A1LMNA
SCHEMBL5126193 0.79 ADORA1 (0.47) ALDH1A1LMNAADORA1MAP4K4KDR
SCHEMBL25387709 0.78 SYK (0.37) SYKL3MBTL1ABL1ALDH1A1LMNA
SCHEMBL30586329 0.78 SYK (0.37) SYKL3MBTL1ABL1ALDH1A1LMNA
SCHEMBL123133 0.78 L3MBTL1 (0.36) SYKL3MBTL1ABL1ALDH1A1ERN1
SCHEMBL29999850 0.75 PDCD1 (0.37) SYKL3MBTL1ABL1ALDH1A1
SCHEMBL27088688 0.75 PDCD1 (0.37) SYKL3MBTL1ABL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240383915-A1 OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER GENENTECH, INC. (US) 2024-11-21 — — US disclosed
EP-4320132-A1 OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER Genentech, Inc. (US) 2024-02-14 — — EP disclosed
CN-117083279-A Oxazepine compounds and their use in the treatment of cancer 基因泰克公司 2023-11-17 — — CN disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 — — US disclosed
WO-2022216762-A1 OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER GENENTECH, INC. (US) 2022-10-13 — — WO disclosed
EP-3371191-B1 NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES MERCK SHARP & DOHME (US) 2020-08-26 — — EP disclosed
US-10399972-B2 Tricyclic compounds as inhibitors of mutant IDH enzymes MERCK SHARP & DOHME CORP. (US) 2019-09-03 — — US disclosed
US-20180305352-A1 NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES MERCK SHARP & DOHME CORP. (US) 2018-10-25 — — US disclosed
EP-3371191-A1 NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES Merck Sharp & Dohme Corp. (US) 2018-09-12 — — EP disclosed
WO-2017074914-A1 NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES MERCK SHARP & DOHME CORP. (US) 2017-05-04 — — WO disclosed
US-8461083-B2 Herbicidal compounds SYNGENTA LIMITED (GB) 2013-06-11 — — US disclosed
US-8450243-B2 Herbicidal quinoline and 1,8-naphthyridine compounds SYNGENTA LIMITED (GB) 2013-05-28 — — US disclosed
EP-2417132-B1 HERBICIDAL QUINOLINE AND 1,8-NAPHTHYRIDINE COMPOUNDS SYNGENTA LTD (GB) 2013-04-17 — — EP disclosed
US-20120094833-A1 HERBICIDAL QUINOLINE AND 1,8 -NAPHTHYRIDINE COMPOUNDS SYNGENTA CROP PROTECTION, LLC (US) 2012-04-19 — — US disclosed
EP-2265120-B1 HERBICIDAL COUMPOUNDS SYNGENTA LTD (GB) 2012-03-07 — — EP disclosed
EP-2417132-A2 HERBICIDAL QUINOLINE AND 1,8-NAPHTHYRIDINE COMPOUNDS Syngenta Limited (GB) 2012-02-15 — — EP disclosed
US-20110021352-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, INC. (US) 2011-01-27 — — US disclosed
EP-2265120-A1 HERBICIDAL COUMPOUNDS Syngenta Limited (GB) 2010-12-29 — — EP disclosed
WO-2010116122-A2 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2010-10-14 — — WO disclosed
WO-2009115788-A1 HERBICIDAL COUMPOUNDS SYNGENTA LIMITED (GB) 2009-09-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10399972-B2 Tricyclic compounds as inhibitors of mutant IDH enzymes IDH3A, IDH3B, IDH2 SYK 3783/4885L3MBTL1 3220/4885ABL1 165/4885
US-20180305352-A1 NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES IDH3B, IDH3A, IDH2 SYK 4168/4885L3MBTL1 3225/4885ABL1 160/4885
US-20120094833-A1 HERBICIDAL QUINOLINE AND 1,8 -NAPHTHYRIDINE COMPOUNDS NQO2, QDPR, CYP4X1 SYK 3879/4885L3MBTL1 2891/4885ABL1 346/4885
US-20110021352-A1 HERBICIDAL COMPOUNDS RDX, NQO2, DDT SYK 3883/4885L3MBTL1 2024/4885ABL1 575/4885
US-20240383915-A1 OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER OXA1L, GRIK4, GRIK5 SYK 2559/4885L3MBTL1 3131/4885ABL1 2592/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.