Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011747 | 1.00 | ALDH1A1 (0.65) | ALDH1A1RAB9AKMT2APSEN1PSEN2 | |
| SCHEMBL2013820 | 0.91 | ALDH1A1 (0.69) | ALDH1A1RAB9AKMT2APSEN1PSEN2 | |
| SCHEMBL2014926 | 0.85 | ALDH1A1 (0.57) | ALDH1A1RAB9AKMT2APSEN1PSEN2 | |
| SCHEMBL12629075 | 0.85 | ALDH1A1 (0.57) | ALDH1A1RAB9AKMT2AMAPTLMNA | |
| SCHEMBL2013828 | 0.85 | ALDH1A1 (0.57) | ALDH1A1RAB9AKMT2AMAPTLMNA | |
| SCHEMBL12628172 | 0.85 | ALDH1A1 (0.57) | ALDH1A1RAB9AKMT2APSEN1PSEN2 | |
| SCHEMBL2036513 | 0.83 | ALDH1A1 (0.55) | ALDH1A1RAB9AKMT2APSEN1PSEN2 | |
| SCHEMBL12631357 | 0.83 | ALDH1A1 (0.55) | ALDH1A1RAB9AKMT2APSEN1PSEN2 | |
| SCHEMBL12631367 | 0.82 | ALDH1A1 (0.53) | ALDH1A1RAB9AKMT2APSEN1PSEN2 | |
| SCHEMBL12628187 | 0.82 | ALDH1A1 (0.53) | ALDH1A1RAB9AKMT2APSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073277-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS Kv1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073269-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |