Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7446113 | 0.85 | MEN1 (0.49) | GBA1MEN1KMT2AHTR6GFER | |
| SCHEMBL21799757 | 0.84 | GBA1 (0.66) | GBA1SLC6A4EP300HRH3HRH4 | |
| Tert-Butyl Formate SCHEMBL28010204 | 0.82 | GBA1 (0.46) | GBA1SLC6A4MEN1KMT2AEP300 | |
| SCHEMBL26528992 | 0.81 | ALDH1A1 (0.50) | GBA1MEN1KMT2AHTR6GFER | |
| SCHEMBL7438487 | 0.81 | NFE2L2 (0.47) | GBA1MEN1KMT2AHTR6HRH3 | |
| SCHEMBL27410823 | 0.81 | GFER (0.46) | GBA1SLC6A4EP300HRH3GFER | |
| SCHEMBL25133603 | 0.80 | GBA1 (0.66) | GBA1SLC6A4EP300HTR6HRH3 | |
| SCHEMBL15718702 | 0.80 | GBA1 (0.66) | GBA1SLC6A4EP300HRH3HRH4 | |
| SCHEMBL4245166 | 0.80 | GBA1 (0.66) | GBA1SLC6A4MEN1KMT2AEP300 | |
| SCHEMBL895063 | 0.80 | GBA1 (0.66) | GBA1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102558093-B | Agents for preventing and treating disorders involving modulation of the RYR receptors | THE TRUSTEES OF COLUMBIA UNIV. IN THE CITY OF NEW YORK (US) | 2014-10-15 | — | — | CN | disclosed |
| EP-2764867-A1 | Agents for preventing and treating disorders Involving modulation of the RYR receptors | The Trustees of Columbia University in the City of New York (US) | 2014-08-13 | — | — | EP | disclosed |
| EP-2764867-A1 | Agents for preventing and treating disorders Involving modulation of the RYR receptors | The Trustees of Columbia University in the City of New York (US) | 2014-08-13 | — | — | EP | disclosed |
| CN-101500576-B | Agents for the prevention and treatment of disorders involving modulation of RYR receptors | UNIV COLUMBIA | 2013-08-14 | — | — | CN | disclosed |
| CN-102558093-A | Agents for preventing and treating disorders involving modulation of the ryr receptors | UNIV COLUMBIA | 2012-07-11 | — | — | CN | disclosed |
| US-8022058-B2 | Agents for preventing and treating disorders involving modulation of the RyR receptors | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-09-20 | — | — | US | disclosed |
| US-8022058-B2 | Agents for preventing and treating disorders involving modulation of the RyR receptors | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-09-20 | — | — | US | disclosed |
| US-8022058-B2 | Agents for preventing and treating disorders involving modulation of the RyR receptors | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-09-20 | — | — | US | disclosed |
| EP-2311464-A1 | Agents for preventing and treating disorders involving modulation of the ryr receptors | The Trustees of Columbia University in the City of New York (US) | 2011-04-20 | — | — | EP | disclosed |
| WO-2011044537-A2 | METHODS FOR TREATING ALZHEIMER'S DISEASE | AFRAXIS, INC. (US) | 2011-04-14 | — | — | WO | disclosed |
| US-20030036655-A1 | 2-(substituted-phenyl)amino-imidazoline derivatives | BLEY KEITH ROGER (US) | 2003-02-20 | — | — | US | disclosed |
| EP-0763535-B1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GMBH (DE) | 2002-11-27 | — | — | EP | disclosed |
| US-6472536-B1 | SUCH AS 2-(4-(4-CYCLOPENTYLOXYBENZYL)PHENYL)AMINO-IMIDAZOLINE; ANTINOCICEPTIVE AGENTS; IP RECEPTOR ANTAGONISTS; TREATING INFLAMMATORY PAIN | SYNTEX (U.S.A.) LLC | 2002-10-29 | — | — | US | disclosed |
| CN-1067391-C | Piperidyl methyl oxazolidinone | MERCK PATENT GMBH (DE) | 2001-06-20 | — | — | CN | disclosed |
| US-6184242-B1 | 2-(substituted-phenyl)amino-imidazoline derivatives | SYNTEX USA (LLC) | 2001-02-06 | — | — | US | disclosed |
| CN-1216762-A | 2-(arylphenyl) amino-imidazoline derivatives | HOFMMANN LA ROCHE AG F (CH) | 1999-05-19 | — | — | CN | disclosed |
| EP-0902018-A2 | 2-(Arylphenyl)amino-imidazoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5714502-A | Piperidinylmethyloxazolidinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-02-03 | — | — | US | disclosed |
| CN-1148594-A | Piperidyl methyl oxazolidinone | MERCK PATENT GMBH (DE) | 1997-04-30 | — | — | CN | disclosed |
| EP-0763535-A1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036655-A1 | 2-(substituted-phenyl)amino-imidazoline derivatives | GIPR, TBXA2R, GRK2 | GBA1 4027/4885SLC6A4 1007/4885MEN1 1906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.