Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3155441 | 0.98 | NFE2L2 (0.50) | NFE2L2MEN1KMT2AALDH1A1HTR6 | |
| SCHEMBL7446113 | 0.91 | MEN1 (0.49) | MEN1KMT2AALDH1A1HTR6GFER | |
| SCHEMBL23314833 | 0.85 | GBA1 (0.50) | NFE2L2MEN1KMT2AGBA1 | |
| SCHEMBL40077 | 0.83 | MEN1 (0.44) | MEN1KMT2AALDH1A1HTR6GFER | |
| Ammonia Solution, Strong SCHEMBL14343979 | 0.81 | MEN1 (0.43) | MEN1KMT2AALDH1A1HTR6GFER | |
| SCHEMBL2627277 | 0.81 | MEN1 (0.43) | MEN1KMT2AALDH1A1HTR6GFER | |
| SCHEMBL1264017 | 0.81 | GBA1 (0.66) | MEN1KMT2AALDH1A1HTR6GFER | |
| SCHEMBL21471559 | 0.80 | LMNA (0.47) | MEN1KMT2AALDH1A1LTA4HHRH3 | |
| SCHEMBL10229753 | 0.80 | LTA4H (0.46) | LTA4HHRH3LOXL2GBA1 | |
| SCHEMBL21767250 | 0.79 | ALDH1A1 (0.44) | NFE2L2MEN1KMT2AALDH1A1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |