Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GPR39 | O43194 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13056389 | 0.88 | CYP3A4 (0.45) | KDM4ECLK4DYRK1ACYP3A4GPR39 | |
| SCHEMBL12646947 | 0.83 | KDM4E (0.48) | KDM4ECLK4DYRK1AGPR39POLB | |
| SCHEMBL10284256 | 0.77 | CYP3A4 (0.44) | KDM4ECLK4DYRK1ACYP3A4POLB | |
| SCHEMBL12646870 | 0.76 | CLK4 (0.42) | KDM4ECLK4DYRK1AALDH1A1 | |
| SCHEMBL12927279 | 0.76 | P2RX7 (0.40) | KDM4EGPR39POLB | |
| SCHEMBL13057606 | 0.75 | PTGDR2 (0.37) | KDM4ECLK4DYRK1AGPR39 | |
| SCHEMBL12647025 | 0.74 | GPR55 (0.49) | KDM4EALDH1A1 | |
| SCHEMBL12960537 | 0.74 | P2RX7 (0.41) | KDM4EPOLB | |
| SCHEMBL13056490 | 0.74 | FABP1 (0.45) | KDM4ECLK4CYP3A4POLBCYP1A2 | |
| SCHEMBL13056388 | 0.72 | CSF1R (0.52) | ACHECCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158957-A2 | KINASE MODULATION AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2012-11-22 | — | — | WO | disclosed |