D,L-Threo-3-Hydroxyaspartic Acid

D,L-Threo-3-Hydroxyaspartic Acid

SCHEMBL12648656

N[C@@H](C(=O)O)[C@@H](O)C(=O)O

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.56
SLC7A5 Q01650 1/20 0.50
USP2 O75604 1/20 0.44
SLCO1B1 Q9Y6L6 1/20 0.44
SLC1A3 P43003 5/20 0.42
SLC1A2 P43004 5/20 0.42
SLC1A1 P43005 5/20 0.42
TP53 P04637 1/20 0.37
CYP2C9 P11712 2/20 0.36
PDE4A P27815 1/20 0.36
PTGS1 P23219 2/20 0.35
NR1I2 O75469 1/20 0.35
ADRA1A P35348 1/20 0.35
LMNA P02545 1/20 0.35
BLM P54132 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
SLC7A11 Q9UPY5 1/20 0.35
MEN1 O00255 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL2367279 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL336363 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL336362 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL13517377 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL5019049 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL2553076 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL336361 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL1130719 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL16237980 0.97 TSHR (0.53) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL8200338 0.97 TSHR (0.53) TSHRSLC7A5USP2SLCO1B1SLC1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120923362-A Novel synthesis method of L (-) -threo-3-hydroxy aspartic acid hydrochloride 深圳市第二人民医院(深圳市转化医学研究院) 2025-11-11 CN disclosed
CN-120923362-A Novel synthesis method of L (-) -threo-3-hydroxy aspartic acid hydrochloride 深圳市第二人民医院(深圳市转化医学研究院) 2025-11-11 CN disclosed
EP-4404933-A1 OXADIAZASPIRO COMPOUNDS FOR USE IN THE TREATMENT OF MOTONEURON DEGENERATION OR IN NEUROPROTECTION ESTEVE PHARMACEUTICALS, S.A. (ES) 2024-07-31 EP disclosed
CN-118339316-A Analysis method 株式会社电装 2024-07-12 CN disclosed
WO-2023100567-A1 ANALYSIS METHOD 株式会社デンソー 2023-06-08 WO disclosed
CN-115855846-A Detection method 株式会社电装 2023-03-28 CN disclosed
WO-2023041713-A1 OXADIAZASPIRO COMPOUNDS FOR USE IN THE TREATMENT OF MOTONEURON DEGENERATION OR IN NEUROPROTECTION ESTEVE PHARMACEUTICALS, S.A. (ES) 2023-03-23 WO disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
CN-115219443-A Conjugate 株式会社电装 2022-10-21 CN disclosed
US-9034798-B2 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions CAPROTEC BIOANALYTICS GMBH (DE) 2015-05-19 US disclosed
US-8569481-B2 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions PHARMACEUTICALS, INC. (US) 2013-10-29 US disclosed
US-20110118136-A1 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions KOESTER HUBERT 2011-05-19 US disclosed
US-20100298168-A1 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions HK PHARMACEUTICALS, INC. 2010-11-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110118136-A1 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions PTMS, QPCTL, SRMS TSHR 3135/4885SLC7A5 1848/4885USP2 1429/4885
US-20100298168-A1 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions CHLSN, PTMS, SRMS TSHR 4673/4885SLC7A5 3966/4885USP2 1492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.