D,L-Threo-3-Hydroxyaspartic Acid

D,L-Threo-3-Hydroxyaspartic Acid

SCHEMBL336361

N[C@H](C(=O)O)C(O)C(=O)O

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.56
SLC7A5 Q01650 1/20 0.50
USP2 O75604 1/20 0.44
SLCO1B1 Q9Y6L6 1/20 0.44
SLC1A3 P43003 5/20 0.42
SLC1A2 P43004 5/20 0.42
SLC1A1 P43005 5/20 0.42
TP53 P04637 1/20 0.37
CYP2C9 P11712 2/20 0.36
PDE4A P27815 1/20 0.36
PTGS1 P23219 2/20 0.35
NR1I2 O75469 1/20 0.35
ADRA1A P35348 1/20 0.35
LMNA P02545 1/20 0.35
BLM P54132 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
SLC7A11 Q9UPY5 1/20 0.35
MEN1 O00255 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL2367279 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL336363 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL336362 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL13517377 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL5019049 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL2553076 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL1130719 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL12648656 1.00 TSHR (0.56) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL16237980 0.97 TSHR (0.53) TSHRSLC7A5USP2SLCO1B1SLC1A3
D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL8200338 0.97 TSHR (0.53) TSHRSLC7A5USP2SLCO1B1SLC1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552839-B2 Cyclic peptides for protection against respiratory syncytial virus VIROMETIX AG (CH) 2026-02-17 US claimed
US-20250177537-A1 AN ANTIBIOTIC, METHOD OF PREPARATION AND METHOD OF TREATMENT THEREOF NATIONAL TAIWAN UNIVERSITY (TW) 2025-06-05 US claimed
CN-114778653-B Metabolism marker combination and screening method for tracing mutton producing area and application 中国农业科学院农业质量标准与检测技术研究所 2024-09-27 CN claimed
US-20240287143-A1 CYCLIC PEPTIDES FOR PROTECTION AGAINST RESPIRATORY SYNCYTIAL VIRUS Universität Zürich (CH) 2024-08-29 US claimed
CN-118019417-A Preparation method and application of electron transport layer solution with uniform passivation effect of photoactive layer 上海交通大学 2024-05-10 CN claimed
EP-4295866-A2 CYCLIC PEPTIDES FOR PROTECTION AGAINST RESPIRATORY SYNCYTIAL VIRUS Virometix AG (CH) 2023-12-27 EP claimed
CN-117106189-A Metal organic framework artificial hydrolase and preparation method and application thereof 华南理工大学 2023-11-24 CN claimed
EP-3638284-B1 CYCLIC PEPTIDES FOR PROTECTION AGAINST RESPIRATORY SYNCYTIAL VIRUS VIROMETIX AG (CH) 2023-08-30 EP claimed
CN-116670151-A Antibacterial cyclic peptides targeting acinetobacter and other gram negative pathogens 犹他大学研究基金会 2023-08-29 CN claimed
CN-115247144-B Genetically engineered bacterium for producing L-threo-3-hydroxy aspartic acid and application thereof 中国科学院青岛生物能源与过程研究所 2023-07-11 CN claimed
US-5518906-A MUTANT ESCHERICHIA MICROBE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-05-21 US claimed
EP-0668358-A1 Antibiotic WAP-8294A, method for preparing the same and antibacterial composition Wakamoto Pharmaceutical Co., Ltd. (JP) 1995-08-23 EP claimed
CN-1095105-A Production of D-pantoic acid and D-pantothenic acid TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1994-11-16 CN claimed
EP-0590857-A2 Production of D-pantoic acid and D-pantothenic acid TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-04-06 EP claimed
EP-0226304-B1 COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC SANKYO COMPANY LIMITED (JP) 1991-08-28 EP claimed
US-4757066-A Reduces renal toxicity SANKYO COMPANY LIMITED (JP) 1988-07-12 US claimed
EP-0226304-A1 Composition containing a penem or carbapenem antibiotic SANKYO COMPANY LIMITED (JP) 1987-06-24 EP claimed
US-4452782-A IMMUNOPOTENTIATING AGENTS HOFFMANN-LA ROCHE INC. (US) 1984-06-05 US claimed
EP-0019072-B1 PENTADECAPEPTIDE, PROCESS FOR THE PREPARATION THEREOF AND IMMUNOPOTENTIATING AGENT F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1983-09-14 EP claimed
EP-0019072-A1 Pentadecapeptide, process for the preparation thereof and immunopotentiating agent F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1980-11-26 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240287143-A1 CYCLIC PEPTIDES FOR PROTECTION AGAINST RESPIRATORY SYNCYTIAL VIRUS VIP, QPCT, QPCTL TSHR 1073/4885SLC7A5 196/4885USP2 1530/4885
US-12552839-B2 Cyclic peptides for protection against respiratory syncytial virus CTH, VIP, CXCL10 TSHR 1606/4885SLC7A5 37/4885USP2 1887/4885
US-20250177537-A1 AN ANTIBIOTIC, METHOD OF PREPARATION AND METHOD OF TREATMENT THEREOF BTD, CALCR, CA6 TSHR 3789/4885SLC7A5 3318/4885USP2 3593/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.