Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.43 |
| ▸ | DHFR | P00374 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787855 | 0.78 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1DHFRMEN1ALDH1A1 | |
| SCHEMBL1059523 | 0.77 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1MEN1ALDH1A1KMT2A | |
| SCHEMBL12652116 | 0.71 | CYP3A4 (0.39) | MEN1ALDH1A1HPGDKMT2ATDP1 | |
| SCHEMBL4269165 | 0.70 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1DHFRMEN1ALDH1A1 | |
| SCHEMBL3393795 | 0.65 | DHFR (0.51) | HSP90AA1HSP90AB1DHFR | |
| SCHEMBL3804748 | 0.62 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1 | |
| SCHEMBL13539955 | 0.62 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1 | |
| SCHEMBL12496384 | 0.61 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1DHFRMEN1ALDH1A1 | |
| SCHEMBL18480805 | 0.61 | PTGS2 (0.50) | HSP90AA1HSP90AB1MAPTACHE | |
| SCHEMBL3396061 | 0.61 | DHFR (0.57) | HSP90AA1HSP90AB1DHFRMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124634-A1 | BIOACTIVE COMPOUNDS FOR TREATMENT OF CANCER AND NEURODEGENERATIVE DISEASES | PONIARD PHARMACEUTICALS, INC. | 2011-05-26 | — | — | US | disclosed |
| WO-2009139834-A1 | BIOACTIVE COMPOUNDS FOR TREATMENT OF CANCER AND NEURODEGENERATIVE DISEASES | PONIARD PHARMACEUTICALS, INC. (US) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124634-A1 | BIOACTIVE COMPOUNDS FOR TREATMENT OF CANCER AND NEURODEGENERATIVE DISEASES | PARK7, BDNF, BACE1 | HSP90AA1 1418/4885HSP90AB1 667/4885DHFR 1825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.