Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | KIF18A | Q8NI77 | 4/20 | 0.34 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | KIT | P10721 | 2/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655442 | 0.90 | GPR52 (0.36) | TRPV3KIF18AGPR52CA2CA9 | |
| SCHEMBL17655393 | 0.83 | GPR52 (0.37) | TRPV3KIF18AGPR52CA2CA9 | |
| SCHEMBL12653790 | 0.83 | RAF1 (0.35) | TRPV3GPR52CA2CA9TRPV1 | |
| SCHEMBL17655423 | 0.81 | CA2 (0.37) | TRPV3GPR52CA2CA9CNR2 | |
| SCHEMBL17655422 | 0.81 | KIF18A (0.36) | TRPV3KIF18AGPR52CA2CA9 | |
| SCHEMBL12653830 | 0.80 | RAF1 (0.35) | TRPV3GPR52CA2CA9NPY5R | |
| SCHEMBL12654419 | 0.80 | PHGDH (0.41) | CA2CA9CNR2PHGDHTRPV1 | |
| SCHEMBL12653796 | 0.80 | CA2 (0.37) | TRPV3CA2CA9CSF1RKIT | |
| SCHEMBL17655380 | 0.78 | FGFR4 (0.41) | CA2CA9CSF1RKITPDGFRA | |
| SCHEMBL12654436 | 0.77 | MPL (0.44) | CA2CA9CSF1RKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |