Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 5/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655393 | 0.94 | GPR52 (0.37) | KIF18AGPR52CA2CA9PRMT5 | |
| SCHEMBL12654540 | 0.87 | TRPV1 (0.34) | GPR52CA2CA9PRMT5WDR77 | |
| SCHEMBL17655442 | 0.87 | GPR52 (0.36) | KIF18AGPR52CA2CA9PRMT5 | |
| SCHEMBL12654418 | 0.85 | CA2 (0.37) | GPR52CA2CA9PRMT5WDR77 | |
| SCHEMBL12653833 | 0.84 | CA2 (0.38) | GPR52CA2CA9PRMT5WDR77 | |
| SCHEMBL12654532 | 0.83 | PRMT5 (0.39) | CA2CA9PRMT5WDR77TRPV3 | |
| SCHEMBL12654420 | 0.82 | RAF1 (0.35) | GPR52CA2CA9PRMT5WDR77 | |
| SCHEMBL18415686 | 0.82 | FGFR4 (0.44) | GPR52PRMT5WDR77FGFR4 | |
| SCHEMBL1816951 | 0.82 | PHGDH (0.41) | CA2CA9KMOTRPV1FGFR4 | |
| SCHEMBL12654528 | 0.81 | TRPV3 (0.36) | KIF18AGPR52CA2CA9TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |