SCHEMBL12655434

SCHEMBL12655434

CC(C)(C)OC(=O)c1cc2c(Br)sc(Br)c2s1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.36
LCK P06239 1/20 0.32
GABRA1 P14867 2/20 0.31
GABRG2 P18507 2/20 0.31
GABRB3 P28472 2/20 0.31
GABRA3 P34903 2/20 0.31
GABRA2 P47869 2/20 0.31
GRM6 O15303 1/20 0.31
CSNK2A2 P19784 1/20 0.31
KDR P35968 1/20 0.31
CSNK2B P67870 1/20 0.31
CSNK2A1 P68400 1/20 0.31
TSHR P16473 1/20 0.31
HSD17B10 Q99714 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
NPC1 O15118 1/20 0.31
PKM P14618 1/20 0.31
JAK2 O60674 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12622629 0.83 CSNK2A2 (0.45) ALDH1A1CSNK2A2KDRCSNK2BCSNK2A1
SCHEMBL12523488 0.78 CLK1 (0.36) ALDH1A1TSHRNPSR1
SCHEMBL1659859 0.75 GPR35 (0.50) ALDH1A1CSNK2A1PKM
SCHEMBL17181085 0.73 GSK3B (0.40) ALDH1A1TSHRHSD17B10NPC1PKM
SCHEMBL18099183 0.71 ESR1 (0.36) TSHRHSD17B10NPC1JAK2JAK1
SCHEMBL15464172 0.70 PRKCA (0.36) ALDH1A1LCKPKM
SCHEMBL31651689 0.70 HDAC3 (0.38) ALDH1A1LCKSTING1
SCHEMBL9986300 0.69 L3MBTL1 (0.42) TSHRHSD17B10CYP2C9CYP2C19NPC1
SCHEMBL1753907 0.69 CES2 (0.53) ALDH1A1LCKHSD17B10NPSR1NPC1
SCHEMBL5043396 0.69 CES2 (0.53) ALDH1A1TSHRHSD17B10CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110124822-A1 SEMICONDUCTING POLYMERS NATIONAL SCIENCE FOUNDATION 2011-05-26 US disclosed