Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12656341 | 0.83 | NEK2 (0.45) | NEK2KDM4EALDH1A1OPRM1OPRD1 | |
| SCHEMBL12656373 | 0.80 | NEK2 (0.50) | NEK2ALDH1A1TSHRNSD2SMN1; SMN2 | |
| SCHEMBL12627055 | 0.79 | NEK2 (1.00) | NEK2KDM4EOPRM1 | |
| SCHEMBL12662735 | 0.78 | NEK2 (0.56) | NEK2OPRM1OPRD1OPRK1 | |
| SCHEMBL12624822 | 0.75 | NEK2 (0.66) | NEK2OPRM1 | |
| SCHEMBL21673277 | 0.72 | PDCD1LG2 (0.38) | NEK2KDM4EALDH1A1OPRM1OPRD1 | |
| SCHEMBL12626437 | 0.72 | KDM1A (0.53) | NEK2TSHR | |
| SCHEMBL4035058 | 0.71 | NEK2 (0.61) | NEK2KDM4EALDH1A1GAA | |
| SCHEMBL8029442 | 0.70 | NEK2 (0.65) | NEK2KDM4EALDH1A1GAATSHR | |
| SCHEMBL12673040 | 0.70 | TSHR (0.41) | KDM4EALDH1A1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105487-A1 | FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC | PAIN THERAPEUTICS | 2011-05-05 | — | — | US | disclosed |
| US-20110105481-A1 | FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC | PAIN THERAPEUTICS | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105487-A1 | FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC | FLNA, FLNB, FPR1 | NEK2 837/4885KDM4E 2871/4885ALDH1A1 3041/4885 |
| US-20110105481-A1 | FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC | FLNA, FLNB, OPRK1 | NEK2 883/4885KDM4E 3242/4885ALDH1A1 2575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.