Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piracetam SCHEMBL6140872 | 0.65 | TSHR (1.00) | TSHRAPEX1BLMALDH1A1KMT2A | |
| SCHEMBL718384 | 0.65 | TSHR (0.66) | TSHRAPEX1BLMKDM4EALDH1A1 | |
| Piracetam SCHEMBL20172 | 0.65 | TSHR (1.00) | TSHRAPEX1BLMALDH1A1KMT2A | |
| Piracetam SCHEMBL28423013 | 0.63 | TSHR (0.96) | TSHRAPEX1BLMALDH1A1KMT2A | |
| SCHEMBL2617910 | 0.63 | TSHR (0.63) | TSHRAPEX1BLMKDM4EMEN1 | |
| Piracetam SCHEMBL28029064 | 0.63 | TSHR (0.86) | TSHRAPEX1BLMALDH1A1KMT2A | |
| SCHEMBL6386673 | 0.62 | TSHR (0.67) | TSHRAPEX1BLMKDM4EALDH1A1 | |
| SCHEMBL3715423 | 0.61 | PIK3CD (0.53) | TSHRAPEX1BLM | |
| SCHEMBL24191960 | 0.60 | PAX8 (0.31) | APEX1BLM | |
| SCHEMBL24263535 | 0.60 | TSHR (0.89) | TSHRAPEX1BLMALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316829-A1 | Heterocyclic derivatives as modulators of ion channels | Vertex Pharmaceuticals Incorporated (US) | 2011-05-04 | — | — | EP | disclosed |