Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 13/20 | 0.51 |
| ▸ | HTR5A | P47898 | 8/20 | 0.47 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | HTR1A | P08908 | 6/20 | 0.47 |
| ▸ | HTR7 | P34969 | 6/20 | 0.47 |
| ▸ | HTR1D | P28221 | 5/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16685040 | 0.78 | HTR2C (0.41) | HTR2CMEN1KMT2A | |
| SCHEMBL16685041 | 0.77 | CHRNB2 (0.40) | HTR2CHTR1AMEN1KMT2AHTR2B | |
| SCHEMBL28210322 | 0.77 | HTR2C (0.33) | HTR2CHTR5AHTR2AHTR1AHTR7 | |
| SCHEMBL12475876 | 0.77 | CHRNB2 (0.40) | HTR2CMEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL16684948 | 0.77 | MAPKAPK2 (0.38) | HTR2CHTR5AHTR2AHTR1AHTR7 | |
| SCHEMBL24240924 | 0.77 | HTR2C (0.33) | HTR2CHTR5AHTR2AHTR1AHTR7 | |
| SCHEMBL21237266 | 0.76 | CA2 (0.38) | HTR2C | |
| SCHEMBL26339836 | 0.74 | GABRA1 (0.36) | HTR2CHTR2B | |
| SCHEMBL24786827 | 0.74 | HTR2C (0.32) | HTR2C | |
| SCHEMBL31402356 | 0.73 | HTR5A (0.41) | HTR2CHTR5AHTR2AHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066344-A1 | 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE | ARENA PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |