Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1266968 | 0.88 | ALDH1A1 (0.62) | ADRA2CALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL1267260 | 0.87 | ADRA2C (0.58) | ADRA2CALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL1267049 | 0.87 | ADRA2C (0.58) | ADRA2CALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL1267519 | 0.81 | MAPT (0.60) | ADRA2CALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL1266067 | 0.81 | ADRA2C (0.58) | ADRA2CALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL1266335 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KDM4EL3MBTL1MAPTNPSR1 | |
| SCHEMBL1267511 | 0.81 | ALDH1A1 (0.47) | ADRA2CALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL1267030 | 0.80 | ADRA2C (0.59) | ADRA2CALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL1266892 | 0.80 | ALDH1A1 (0.50) | ADRA2CALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL1267602 | 0.79 | ADRA2C (0.58) | ADRA2CALDH1A1KDM4EL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879858-B2 | monoamine reuptake inhibitors such as (3-fluorophenyl)(1-(2-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone, used as antidepressants, anxiolytic agents and analgesics | GRUENENTHAL GMBH (DE) | 2011-02-01 | — | — | US | claimed |
| EP-2144913-A2 | SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE COMPOUNDS AS MONOAMINE REUPTAKE INHIBITORS AND USE THEREOF AS MEDICAMENTS | Grünenthal GmbH (DE) | 2010-01-20 | — | — | EP | claimed |
| US-20090258880-A1 | Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions | GRUENENTHAL GMBH (DE) | 2009-10-15 | — | — | US | claimed |
| WO-2008046581-A2 | SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE COMPOUNDS AND USE THEREOF IN MEDICAMENTS | Grünenthal GmbH (DE) | 2008-04-24 | — | — | WO | claimed |
| US-7879858-B2 | monoamine reuptake inhibitors such as (3-fluorophenyl)(1-(2-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone, used as antidepressants, anxiolytic agents and analgesics | GRUENENTHAL GMBH (DE) | 2011-02-01 | — | — | US | disclosed |
| US-20090258880-A1 | Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions | GRUENENTHAL GMBH (DE) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258880-A1 | Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions | DHPS, APC, CYP3A5 | ADRA2C 185/4885ALDH1A1 559/4885KDM4E 2341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.