Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.39 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 2/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16939264 | 0.80 | MME (0.69) | MMEMMP2MMP3TAAR1ACE | |
| SCHEMBL11969564 | 0.80 | MME (0.69) | MMEMMP2MMP3TAAR1ACE | |
| SCHEMBL19222886 | 0.80 | MME (0.60) | MMEMMP2MMP3ACEMMEL1 | |
| SCHEMBL3466739 | 0.79 | MMP2 (0.52) | MMEMMP2MMP3TAAR1ACE | |
| SCHEMBL7918296 | 0.76 | MMP2 (0.56) | MMEMMP2MMP3TAAR1HCAR2 | |
| SCHEMBL19888579 | 0.76 | MME (0.59) | MMEMMP2MMP3TAAR1ACE | |
| SCHEMBL14891213 | 0.75 | MME (0.73) | MMEACEMMEL1 | |
| SCHEMBL11969971 | 0.75 | MME (0.70) | MMEMMP2MMP3ACEMMEL1 | |
| SCHEMBL11973757 | 0.75 | MME (0.70) | MMEMMP2MMP3ACEMMEL1 | |
| SCHEMBL16975185 | 0.75 | MME (0.49) | MMEMMP2MMP3MMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012112742-A1 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-08-23 | — | — | WO | disclosed |