Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 7/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 2/20 | 0.38 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16975187 | 0.90 | MMEL1 (0.45) | MMEFAAHMAPK1SMN1; SMN2ACACB | |
| SCHEMBL12481768 | 0.80 | MME (0.49) | MMEFAAHACACBMMP2MMP3 | |
| SCHEMBL2707583 | 0.79 | MMEL1 (0.47) | MMEMAPK1SMN1; SMN2ACACBACACA | |
| SCHEMBL2877470 | 0.76 | MMEL1 (0.59) | FAAHSMN1; SMN2ACACBACACAMMEL1 | |
| SCHEMBL8932530 | 0.76 | FAAH (0.51) | FAAHMAPK1SMN1; SMN2ROCK2ROCK1 | |
| SCHEMBL12684793 | 0.75 | MME (0.60) | MMEMMP2MMP3MMEL1 | |
| SCHEMBL2873143 | 0.75 | MMEL1 (0.57) | FAAHSMN1; SMN2ACACBACACAMMEL1 | |
| SCHEMBL12481143 | 0.74 | MMP2 (0.51) | MMEMMP2MMP3MMEL1 | |
| SCHEMBL15564105 | 0.74 | MMEL1 (0.42) | MMEFAAHMAPK1SMN1; SMN2MMEL1 | |
| SCHEMBL16975135 | 0.73 | MME (0.45) | MMEFAAHMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099678-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015116786-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-06 | — | — | WO | disclosed |