Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 2/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PPIB | P23284 | 1/20 | 0.30 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12478249 | 0.86 | TGM2 (0.36) | TGM2CES1CASP3TDP2KDM4E | |
| SCHEMBL12478389 | 0.79 | S100A4 (0.42) | TGM2CES1MAPTAPP | |
| SCHEMBL4260350 | 0.71 | MAPT (0.67) | MAPTHTTGAAKDM4EALDH1A1 | |
| SCHEMBL9475638 | 0.71 | TGM2 (0.42) | TGM2CES1CASP3MAPTTDP2 | |
| SCHEMBL12479215 | 0.70 | BRD4 (0.30) | — | |
| SCHEMBL5543907 | 0.69 | MAPT (0.37) | MAPTTSHRHTTGAAKDM4E | |
| SCHEMBL12686425 | 0.69 | S100A4 (0.42) | TGM2CES1KDM4EALDH1A1 | |
| SCHEMBL12479266 | 0.69 | S100A4 (0.42) | TGM2CES1KDM4EALDH1A1 | |
| SCHEMBL23362956 | 0.68 | CA1 (0.43) | TGM2CES1MAPTAPP | |
| SCHEMBL2433995 | 0.68 | PPOX (0.41) | TGM2CES1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012110860-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-08-23 | — | — | WO | disclosed |