SCHEMBL126903

SCHEMBL126903

COc1ccc(N)c(N)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NNMT P40261 3/20 0.41
SIRT2 Q8IXJ6 1/20 0.41
SIRT1 Q96EB6 1/20 0.41
TDP1 Q9NUW8 3/20 0.38
POLB P06746 1/20 0.38
CYP1A2 P05177 1/20 0.37
KMT2A Q03164 1/20 0.37
ALDH1A1 P00352 5/20 0.37
CYP3A4 P08684 2/20 0.37
TSHR P16473 1/20 0.37
HSD17B10 Q99714 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
ADRA2B P18089 1/20 0.34
PTGS1 P23219 1/20 0.34
IDO1 P14902 1/20 0.34
TLR8 Q9NR97 1/20 0.34
MAP4K4 O95819 1/20 0.34
PLAU P00749 1/20 0.34
EP300 Q09472 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29424844 1.00 NNMT (0.41) NNMTSIRT2SIRT1TDP1POLB
Hydrochloric Acid SCHEMBL3736737 0.98 NNMT (0.40) NNMTSIRT2SIRT1TDP1POLB
Hydrochloric Acid SCHEMBL30078498 0.98 NNMT (0.40) NNMTSIRT2SIRT1TDP1POLB
Hydrochloric Acid SCHEMBL3338097 0.98 NNMT (0.40) NNMTSIRT2SIRT1TDP1POLB
SCHEMBL13657692 0.85 NNMT (0.40) NNMTSIRT2SIRT1
SCHEMBL6027123 0.81 TXNRD1 (0.51) RAB9A
SCHEMBL27235504 0.81 NNMT (0.46) NNMTSIRT2SIRT1TDP1POLB
SCHEMBL29743795 0.79 NNMT (0.53) NNMTSIRT2SIRT1TDP1POLB
SCHEMBL656848 0.79 POLB (0.50) NNMTSIRT2SIRT1TDP1POLB
SCHEMBL30054640 0.79 POLB (0.50) NNMTSIRT2SIRT1TDP1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4240 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10639257-B2 Composition for colouring keratin fibres BEAUTY & BUSINESS S.P.A. (IT) 2020-05-05 US claimed
US-20190117541-A1 COMPOSITION FOR COLOURING KERATIN FIBRES BEAUTY & BUSINESS S.P.A. (IT) 2019-04-25 US claimed
US-9993413-B2 Keratin fibre dyeing composition BEAUTY & BUSINESS S.P.A. (IT) 2018-06-12 US claimed
US-20170258695-A1 KERATIN FIBRE DYEING COMPOSITION BEAUTY & BUSINESS S.P.A. (IT) 2017-09-14 US claimed
EP-1789015-B1 METHOD FOR STYLISHLY CHANGING THE COLOR OF KERATINIC FIBERS HENKEL AG & CO KGAA (DE) 2014-04-23 EP claimed
EP-1778176-B1 COMPOSITION FOR COLOURING KERATIN-CONTAINING FIBRES HENKEL AG & CO KGAA (DE) 2012-07-25 EP claimed
JP-4785024-B2 2011-10-05 JP claimed
US-20110020251-A1 Ultraviolet-Absorbing Compounds AVOCA LLC 2011-01-27 US claimed
CN-1982311-B Synthesis of 2-hydrophobic-5-methoxy-diazole [4,5-b]-dipyridine WEIZHI FINE CHEMICAL CO LTD TIANJIN 2010-10-13 CN claimed
EP-1494995-B1 3-AMINOPHENOL DERIVATIVES SUBSTITUTED IN THE 2-POSITION, AND DYES CONTAINING THESE COMPOUNDS PROCTER & GAMBLE (US) 2010-09-22 EP claimed
WO-1999048465-A1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES CONTAINING A 3-AMINOPYRIDINE AZO DERIVATIVE AND DYEING METHOD USING SAID COMPOSITION L'OREAL (FR) 1999-09-30 WO claimed
EP-0943614-A2 Dyeing agents comprising diaminobenzene derivatives and the diaminobenzene derivatives Wella Aktiengesellschaft (DE) 1999-09-22 EP claimed
WO-1999011230-A1 OXIDATION DYEING COMPOSITION FOR KERATIN FIBRES COMPRISING 2-CHLORO 6 METHYL 3-AMINOPHENOL AND AN OXIDATION BASE, AND DYEING METHOD L'OREAL (FR) 1999-03-11 WO claimed
EP-0502783-B1 Keratinous fibres dyeing process with isatin or derivatives thereof associated with an aminopyridine or an aminopyrimidine and dyeing agents OREAL (FR) 1995-05-03 EP claimed
US-5279616-A Applying to hair inconcentration of .01 to 5 percent L'OREAL (FR) 1994-01-18 US claimed
US-5180399-A Kits for dyeing hair L'OREAL (FR) 1993-01-19 US claimed
EP-0502783-A1 Keratinous fibres dyeing process with isatin or derivatives thereof associated with an aminopyridine or an aminopyrimidine and dyeing agents L'OREAL (FR) 1992-09-09 EP claimed
US-4784667-A DEEP BLUE FINISHES, HEAT AND LIGHT STABLE HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1988-11-15 US claimed
EP-0106987-B1 HAIR DYEING COMPOSITION Henkel Kommanditgesellschaft auf Aktien (DE) 1986-07-30 EP claimed
EP-0106987-A1 Hair dyeing composition Henkel Kommanditgesellschaft auf Aktien (DE) 1984-05-02 EP claimed