SCHEMBL12697276

SCHEMBL12697276

COCC(C)C1=NCCO1

nearest known ligand 0.38

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.38
ADRA2B P18089 1/20 0.38
ADRA2C P18825 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12375095 0.90 ADRA2A (0.35) ADRA2AADRA2BADRA2C
SCHEMBL12770362 0.85 ADRA2A (0.36) ADRA2AADRA2BADRA2C
SCHEMBL12086388 0.83 ADRA2A (0.37) ADRA2AADRA2BADRA2C
SCHEMBL23576314 0.82 ADRA2A (0.35) ADRA2AADRA2BADRA2C
SCHEMBL13863538 0.81 ADRA2A (0.32) ADRA2AADRA2BADRA2C
SCHEMBL12085940 0.80 ADRA2A (0.35) ADRA2AADRA2BADRA2C
SCHEMBL8078236 0.78
SCHEMBL1126029 0.78
SCHEMBL10740588 0.78 ADRA2A (0.34) ADRA2AADRA2BADRA2C
SCHEMBL1126027 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150232616-A1 HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS INTEZYNE TECHNOLOGIES, INC. 2015-08-20 US disclosed
US-8980326-B2 Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents INTEZYNE TECHNOLOGIES, INC. (US) 2015-03-17 US disclosed
US-8426477-B1 Polymeric micelles for drug delivery INTEZYNE TECHNOLOGIES, LLC (US) 2013-04-23 US disclosed
WO-2012126797-A2 USE OF OLIGOMERIC CARBODIIMIDES AS STABILIZERS BASF SE (DE) 2012-09-27 WO disclosed
US-8268936-B2 Synthesis of hybrid block copolymers and uses thereof INTEZYNE TECHNOLOGIES, INC. (US) 2012-09-18 US disclosed
US-8263663-B2 Azide functionalized peptide targeting groups INTEZYNE TECHNOLOGIES, INC. (US) 2012-09-11 US disclosed
US-20110092668-A1 AZIDE FUNCTIONALIZED PEPTIDE TARGETING GROUPS INTEZYNE TECHNOLOGIES, INC. (US) 2011-04-21 US disclosed
US-20110091534-A1 COMPOSITIONS COMPRISING POLYMERIC MICELLES FOR DRUG DELIVERY INTEZYNE TECHNOLOGIES, INC. (US) 2011-04-21 US disclosed
US-20110021718-A1 SYNTHESIS OF HYBRID BLOCK COPOLYMERS AND USES THEREOF INTEZYNE TECHNOLOGIES (US) 2011-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110092668-A1 AZIDE FUNCTIONALIZED PEPTIDE TARGETING GROUPS IAPP, NGLY1, MSN ADRA2A 3617/4885ADRA2B 2438/4885ADRA2C 4056/4885
US-20110091534-A1 COMPOSITIONS COMPRISING POLYMERIC MICELLES FOR DRUG DELIVERY ABCB4, ABCB11, CLTB ADRA2A 2625/4885ADRA2B 1926/4885ADRA2C 2642/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.