Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.71 |
| ▸ | NPC1 | O15118 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.70 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.70 |
| ▸ | NAMPT | P43490 | 6/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790983 | 0.88 | CYP11B1 (0.71) | LMNAHIF1ARAB9ANPC1KDM4E | |
| SCHEMBL790699 | 0.86 | NAMPT (0.73) | LMNAHIF1ARAB9ANPC1CYP11B1 | |
| SCHEMBL1571386 | 0.85 | LMNA (1.00) | LMNAHIF1ARAB9ANPC1CYP11B1 | |
| SCHEMBL13096026 | 0.85 | LMNA (0.69) | LMNAHIF1ARAB9ANPC1CYP11B1 | |
| SCHEMBL13210581 | 0.83 | ALDH1A1 (1.00) | LMNARAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL30834320 | 0.83 | ALDH1A1 (1.00) | LMNARAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL29151323 | 0.83 | PRKCI (0.61) | LMNAHIF1ARAB9ANPC1ALDH1A1 | |
| SCHEMBL30354911 | 0.83 | PRKCI (0.61) | LMNAHIF1ARAB9ANPC1ALDH1A1 | |
| SCHEMBL10978857 | 0.83 | CYP11B1 (1.00) | LMNAHIF1ARAB9ANPC1KDM4E | |
| SCHEMBL16496141 | 0.81 | NAMPT (0.72) | LMNAHIF1ARAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1932834-B1 | Aromatic 1,4-DI-Carboxylamides and their use | GENETICS CO INC (CH) | 2011-04-27 | — | — | EP | disclosed |
| US-20100204219-A1 | AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE | THE GENETICS COMPANY, INC. (CH) | 2010-08-12 | — | — | US | disclosed |
| US-20100204219-A1 | AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE | THE GENETICS COMPANY, INC. (CH) | 2010-08-12 | — | — | US | disclosed |
| WO-2008071397-A1 | AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE | THE GENETICS COMPANY INC. (CH) | 2008-06-19 | — | — | WO | disclosed |
| EP-1932834-A1 | Aromatic 1,4-DI-Carboxylamides and their use | The Genetics Company, Inc. (CH) | 2008-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204219-A1 | AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE | CBR3, CYCS, CYC1 | LMNA 1013/4885HIF1A 1829/4885RAB9A 4749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.