Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 4/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.56 |
| ▸ | ACP1 | P24666 | 4/20 | 0.56 |
| ▸ | BAG3 | O95817 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12712450 | 0.88 | ENPP2 (0.52) | ENPP2PTPN1ACP1BAG3PPARG | |
| SCHEMBL12712437 | 0.87 | ENPP2 (0.64) | ENPP2PTPN1ACP1PPARGMEN1 | |
| SCHEMBL1615013 | 0.87 | SLC2A1 (0.66) | ENPP2PTPN1ACP1BAG3PPARG | |
| SCHEMBL12712430 | 0.85 | PTPN1 (0.56) | ENPP2PTPN1ACP1BAG3PPARG | |
| SCHEMBL1614334 | 0.80 | ENPP2 (0.54) | ENPP2PTPN1ACP1PPARGMEN1 | |
| SCHEMBL1614940 | 0.80 | SLC2A1 (0.52) | ENPP2PTPN1ACP1PPARGMEN1 | |
| SCHEMBL8172925 | 0.78 | AKR1B1 (0.69) | BAG3MCL1 | |
| SCHEMBL12712441 | 0.78 | SLC2A1 (0.57) | PTPN1ACP1BAG3MEN1POLB | |
| SCHEMBL8172926 | 0.78 | AKR1B1 (0.69) | BAG3MCL1 | |
| SCHEMBL16489850 | 0.77 | SLC2A1 (0.79) | PTPN1ACP1BAG3PPARGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383656-B2 | Thiazolidinedione energy restriction-mimetic agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-02-26 | — | — | US | disclosed |
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | PCK2, AK2, SIRT6 | ENPP2 1288/4885PTPN1 863/4885ACP1 1572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.