Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246781 | 0.82 | GPR35 (0.42) | CHRNB2CHRNA4DRD2ADRA2CNPY1R | |
| SCHEMBL2242996 | 0.81 | CHRNB2 (0.35) | CHRNB2CHRNA4DRD2ADRA2CNPY1R | |
| SCHEMBL12355698 | 0.80 | CHRNB2 (0.40) | CHRNB2CHRNA4DRD2ADRA2CNPY1R | |
| SCHEMBL7517485 | 0.78 | TDP1 (0.41) | CHRNB2CHRNA4ERN1TSHRALOX15 | |
| SCHEMBL1415461 | 0.78 | MTNR1A (0.47) | CHRNB2CHRNA4DRD2ADRA2CNPY1R | |
| SCHEMBL1573308 | 0.75 | TDP1 (0.38) | CHRNB2CHRNA4ERN1TSHRTDP1 | |
| SCHEMBL13332612 | 0.75 | MTNR1A (0.44) | — | |
| SCHEMBL5916971 | 0.74 | GPR35 (0.46) | CHRNB2CHRNA4ERN1TSHRALOX15 | |
| SCHEMBL14017372 | 0.74 | TDP1 (0.44) | CHRNB2CHRNA4TSHRALOX15TDP1 | |
| SCHEMBL1080845 | 0.74 | TDP1 (0.44) | CHRNB2CHRNA4TSHRALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048132-B1 | Tetrahydro-naphthalene and urea derivatives | XENTION LTD (GB) | 2011-04-13 | — | — | EP | disclosed |