Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 1.00 |
| ▸ | MEN1 | O00255 | 9/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.87 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | HTT | P42858 | 4/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 6/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12717683 | 0.86 | MAPT (0.87) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7689352 | 0.77 | MAPT (0.78) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL22737353 | 0.72 | MAPT (0.68) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL13091221 | 0.70 | MAPT (0.60) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3813156 | 0.70 | MAPT (0.66) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3063942 | 0.69 | MAPT (0.59) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL14291439 | 0.69 | MAPT (0.59) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL14438981 | 0.69 | MEN1 (0.78) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL14291437 | 0.69 | MAPT (0.58) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL11807869 | 0.68 | NPSR1 (0.93) | MAPTMEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928113-B2 | Integrin-binding small molecules | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7928113-B2 | Integrin-binding small molecules | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-19 | — | — | US | disclosed |
| US-20070155750-A1 | INTEGRIN-BINDING SMALL MOLECULES | USC STEVENS-UNIVERSITY OF SOUTHERN CALIFORNIA | 2007-07-05 | — | — | US | disclosed |
| US-20070155750-A1 | INTEGRIN-BINDING SMALL MOLECULES | USC STEVENS-UNIVERSITY OF SOUTHERN CALIFORNIA | 2007-07-05 | — | — | US | disclosed |
| WO-2007059195-A1 | INTEGRIN-BINDING SMALL MOLECULES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155750-A1 | INTEGRIN-BINDING SMALL MOLECULES | ITGB3, ITGB5, ITGA2B | MAPT 4563/4885MEN1 4015/4885KMT2A 4552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.