Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.68 |
| ▸ | MEN1 | O00255 | 10/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | HTT | P42858 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 6/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 6/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22737807 | 0.78 | MAPT (0.68) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL22737384 | 0.75 | MAPT (0.70) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL13091227 | 0.74 | MAPT (0.61) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL22737369 | 0.74 | GAA (0.59) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL23345459 | 0.74 | KMT2A (0.72) | MAPTKMT2AMEN1HTTKDM4E | |
| SCHEMBL12717683 | 0.73 | MAPT (0.87) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL12717690 | 0.72 | MAPT (1.00) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL1659812 | 0.72 | MAPT (0.62) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL1659816 | 0.72 | MAPT (0.62) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL13091221 | 0.72 | MAPT (0.60) | MAPTKMT2AMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200375996-A1 | METHOD OF TREATING NEURODEGENERATIVE DISORDERS BY RESCUING ALPHA-SYNUCLEIN TOXICITY | D.E. SHAW RESEARCH, LLC (US) | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200375996-A1 | METHOD OF TREATING NEURODEGENERATIVE DISORDERS BY RESCUING ALPHA-SYNUCLEIN TOXICITY | SNCA, PARK7, NEDD4 | MAPT 48/4885KMT2A 2524/4885MEN1 4316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.