Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.60 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.59 |
| ▸ | ITGAV | P06756 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14883357 | 0.76 | ALDH1A1 (0.69) | ITGB3ITGAVALDH1A1POLBMAPT | |
| SCHEMBL12177442 | 0.75 | ALDH1A1 (0.62) | PTPN1ITGB3ITGAVALDH1A1POLB | |
| SCHEMBL12717644 | 0.74 | ITGB3 (1.00) | ITGB3ITGAVALDH1A1POLBMAPT | |
| SCHEMBL12177501 | 0.74 | PTPN2 (0.61) | PTPN1ITGB3ITGAVALDH1A1POLB | |
| SCHEMBL12177731 | 0.74 | PTPN2 (0.61) | PTPN1ITGB3ITGAVALDH1A1POLB | |
| SCHEMBL12177530 | 0.73 | ALDH1A1 (0.59) | PTPN1ITGB3ITGAVALDH1A1POLB | |
| SCHEMBL12177449 | 0.73 | ALDH1A1 (0.61) | PTPN1ITGB3ITGAVALDH1A1POLB | |
| SCHEMBL14876910 | 0.72 | ITGB3 (1.00) | PTPN1ITGB3ITGAVALDH1A1POLB | |
| SCHEMBL14883359 | 0.72 | ITGB3 (1.00) | PTPN1ITGB3ITGAVALDH1A1POLB | |
| SCHEMBL12717615 | 0.72 | ITGB3 (1.00) | PTPN1ITGB3ITGAVALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928113-B2 | Integrin-binding small molecules | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7928113-B2 | Integrin-binding small molecules | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-19 | — | — | US | disclosed |
| EP-2298308-A2 | Integrin-binding small molecules | University Of Southern California (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20070155750-A1 | INTEGRIN-BINDING SMALL MOLECULES | USC STEVENS-UNIVERSITY OF SOUTHERN CALIFORNIA | 2007-07-05 | — | — | US | disclosed |
| US-20070155750-A1 | INTEGRIN-BINDING SMALL MOLECULES | USC STEVENS-UNIVERSITY OF SOUTHERN CALIFORNIA | 2007-07-05 | — | — | US | disclosed |
| WO-2007059195-A1 | INTEGRIN-BINDING SMALL MOLECULES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155750-A1 | INTEGRIN-BINDING SMALL MOLECULES | ITGB3, ITGB5, ITGA2B | PTPN1 2736/4885ITGB3 1/4885ITGAV 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.