Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.85 |
| ▸ | GSK3A | P49840 | 2/20 | 0.71 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.71 |
| ▸ | EGFR | P00533 | 2/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | ABL2 | P42684 | 1/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.61 |
| ▸ | PNP | P00491 | 1/20 | 0.61 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.60 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.60 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.60 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.60 |
| ▸ | LDHA | P00338 | 1/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
| ▸ | FBP1 | P09467 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9605293 | 0.92 | ABCB1 (1.00) | ABCB1GSK3ARPS6KA3MAPK14EGFR | |
| SCHEMBL9607792 | 0.92 | ABCB1 (1.00) | ABCB1GSK3ARPS6KA3MAPK14EGFR | |
| SCHEMBL611618 | 0.92 | ABCB1 (1.00) | ABCB1GSK3ARPS6KA3MAPK14EGFR | |
| SCHEMBL4629734 | 0.92 | ABCB1 (1.00) | ABCB1GSK3ARPS6KA3MAPK14EGFR | |
| Hydrochloric Acid SCHEMBL19666771 | 0.91 | ABCB1 (0.98) | ABCB1GSK3ARPS6KA3MAPK14EGFR | |
| SCHEMBL441535 | 0.88 | ABCB1 (0.77) | ABCB1GSK3ARPS6KA3MAPK14ADORA1 | |
| SCHEMBL11644877 | 0.88 | ABCB1 (0.77) | ABCB1GSK3ARPS6KA3MAPK14ADORA1 | |
| SCHEMBL1272109 | 0.88 | ABCB1 (0.77) | ABCB1GSK3ARPS6KA3MAPK14EGFR | |
| SCHEMBL14471384 | 0.88 | ABCB1 (0.77) | ABCB1GSK3ARPS6KA3MAPK14EGFR | |
| SCHEMBL14025772 | 0.88 | ABCB1 (0.77) | ABCB1GSK3ARPS6KA3MAPK14EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034670-A1 | BISUBSTRATE INHIBITORS OF PROTEIN KINASES AS THERAPEUTIC AGENTS | BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 2011-02-10 | — | — | US | disclosed |
| US-7799753-B2 | Bisubstrate inhibitors of protein tyrosine kinases as therapeutic agents | Board of Governers for Higher Education (US) | 2010-09-21 | — | — | US | disclosed |
| US-20070173437-A1 | BISUBSTRATE INHIBITORS OF PROTEIN TYROSINE KINASES AS THERAPEUTIC AGENTS | RHODE ISLAND BOARD OF EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS | 2007-07-26 | — | — | US | disclosed |
| WO-2005117932-A1 | BISUBSTRATE INHIBITORS OF PROTEIN TYROSINE KINASES AS THERAPEUTIC AGENTS | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034670-A1 | BISUBSTRATE INHIBITORS OF PROTEIN KINASES AS THERAPEUTIC AGENTS | SRC, PDXK, DSTYK | ABCB1 1038/4885GSK3A 1119/4885RPS6KA3 433/4885 |
| US-20070173437-A1 | BISUBSTRATE INHIBITORS OF PROTEIN TYROSINE KINASES AS THERAPEUTIC AGENTS | DSTYK, SRC, PTK2B | ABCB1 975/4885GSK3A 1126/4885RPS6KA3 547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.