Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28689206 | 0.75 | RAB9A (0.54) | GAARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL12727644 | 0.75 | HCAR3 (0.51) | GAANPSR1TDP1MAPTALDH1A1 | |
| SCHEMBL9321802 | 0.75 | TOP2A (1.00) | TOP2AGAANPSR1TDP1RAB9A | |
| SCHEMBL17987719 | 0.75 | TOP2A (1.00) | TOP2AGAANPSR1TDP1RAB9A | |
| SCHEMBL29883013 | 0.75 | TOP2A (1.00) | TOP2AGAANPSR1TDP1RAB9A | |
| SCHEMBL1973299 | 0.74 | RAB9A (0.59) | GAARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL4364365 | 0.73 | NPSR1 (0.63) | GAANPSR1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1024423 | 0.73 | TOP2A (0.75) | TOP2AGAANPSR1TDP1RAB9A | |
| SCHEMBL15028494 | 0.72 | NPC1 (0.45) | GAARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL16701390 | 0.72 | NPSR1 (0.50) | TOP2AGAANPSR1TDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299285-B2 | Compounds for imaging and therapy | ISIS INNOVATION LIMITED (GB) | 2012-10-30 | — | — | US | disclosed |
| US-8299285-B2 | Compounds for imaging and therapy | ISIS INNOVATION LIMITED (GB) | 2012-10-30 | — | — | US | disclosed |
| US-20110098353-A1 | Compounds for Imaging and Therapy | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2011-04-28 | — | — | US | disclosed |
| US-20110098353-A1 | Compounds for Imaging and Therapy | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2011-04-28 | — | — | US | disclosed |
| WO-2007003944-A2 | COMPOUNDS FOR IMAGING AND THERAPY | ISIS INNOVATION LIMITED (GB) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098353-A1 | Compounds for Imaging and Therapy | MEN1, XPOT, SLC39A3 | TOP2A 70/4885GAA 554/4885NPSR1 1626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.