Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 3/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21303019 | 0.84 | ALDH1A1 (0.40) | NPC1HSD11B1ALDH1A1HPGDKMT2A | |
| SCHEMBL12731280 | 0.77 | NPC1 (0.46) | NPC1DPP4HSD11B1USP2ALDH1A1 | |
| SCHEMBL1924207 | 0.74 | DPP4 (0.50) | NPC1DPP4HSD11B1USP2ALDH1A1 | |
| SCHEMBL5848807 | 0.72 | NPC1 (0.60) | NPC1DPP4HSD11B1USP2ALDH1A1 | |
| SCHEMBL16202037 | 0.72 | NPC1 (0.56) | NPC1DPP4HSD11B1USP2ALDH1A1 | |
| SCHEMBL12731279 | 0.72 | NPC1 (0.41) | NPC1DPP4HSD11B1USP2ALDH1A1 | |
| SCHEMBL1660803 | 0.70 | LMNA (0.48) | NPC1DPP4HSD11B1USP2ALDH1A1 | |
| SCHEMBL12360957 | 0.70 | DPP4 (0.46) | NPC1DPP4HSD11B1USP2ALDH1A1 | |
| SCHEMBL1922413 | 0.70 | DPP4 (0.49) | NPC1DPP4CRHR1 | |
| SCHEMBL2255045 | 0.70 | DPP4 (0.49) | NPC1DPP4HSD11B1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086898-A1 | PYRAZOLOOXAZOLE COMPOUND | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086898-A1 | PYRAZOLOOXAZOLE COMPOUND | CRHR1, MC2R, CRHR2 | NPC1 2110/4885DPP4 1019/4885HSD11B1 466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.