Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | MAOA | P21397 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | HTR2B | P41595 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30002207 | 1.00 | NPC1 (0.68) | NPC1RAB9AMAOACYP1A2HTR2B | |
| SCHEMBL9279689 | 0.89 | MAOA (0.66) | NPC1RAB9AMAOACYP1A2HTR2B | |
| SCHEMBL2964564 | 0.84 | MAOA (0.68) | NPC1RAB9AMAOACYP1A2HTR2B | |
| SCHEMBL144325 | 0.81 | NPC1 (1.00) | NPC1RAB9AMAOACYP1A2HTR2B | |
| SCHEMBL15671596 | 0.79 | TERT (0.45) | NPC1RAB9AHTR2BALDH1A1HPGD | |
| SCHEMBL11740054 | 0.77 | NPC1 (0.81) | NPC1RAB9AMAOACYP1A2HTR2B | |
| SCHEMBL2526502 | 0.77 | MAOA (0.45) | NPC1RAB9AMAOACYP1A2HTR2B | |
| Sulfuric Acid SCHEMBL28964142 | 0.76 | NPC1 (0.89) | NPC1RAB9AMAOACYP1A2HTR2B | |
| SCHEMBL16865877 | 0.75 | MAOA (0.59) | NPC1RAB9AMAOACYP1A2ALDH1A1 | |
| SCHEMBL15580935 | 0.75 | MAOA (0.59) | NPC1RAB9AMAOACYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030165854-A1 | Marker genes responding to treatment with toxins | INCYTE GENOMICS, INC. | 2003-09-04 | — | — | US | claimed |
| US-20240052418-A1 | METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-02-15 | — | — | US | disclosed |
| US-11814681-B2 | Method for predicting a subjects response to SLC modulator therapy | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-11-14 | — | — | US | disclosed |
| US-20210254158-A1 | METHOD FOR PREDICTING A SUBJECTS RESPONSE TO SLC MODULATOR THERAPY | RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. | 2021-08-19 | — | — | US | disclosed |
| US-11041207-B2 | Method for predicting a subject's response to valproic acid therapy | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-06-22 | — | — | US | disclosed |
| WO-2019046303-A1 | A METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-07 | — | — | WO | disclosed |
| EP-2710374-B1 | IN VITRO METHOD FOR PREDICTING IN VIVO GENOTOXICITY OF CHEMICAL COMPOUNDS | UNIV MAASTRICHT (NL) | 2016-03-02 | — | — | EP | disclosed |
| CN-104066435-A | Proteolytically resistant hydrogen bond surrogate helices | UNIV NEW YORK | 2014-09-24 | — | — | CN | disclosed |
| EP-2525223-A1 | In vitro method for predicting in vivo genotoxicity of chemical compounds. | Universiteit Maastricht (NL) | 2012-11-21 | — | — | EP | disclosed |
| EP-2491508-A2 | METHOD FOR GENERATING BIOMARKER REFERENCE PATTERNS | BASF Plant Science Company GmbH (DE) | 2012-08-29 | — | — | EP | disclosed |
| US-20120209535-A1 | METHOD FOR GENERATING BIOMARKER REFERENCE PATTERNS | BASF PLANT SCIENCE COMPANY GMBH (DE) | 2012-08-16 | — | — | US | disclosed |
| WO-2011048007-A2 | METHOD FOR GENERATING BIOMARKER REFERENCE PATTERNS | BASF PLANT SCIENCE COMPANY GMBH (DE) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011048007-A2 | METHOD FOR GENERATING BIOMARKER REFERENCE PATTERNS | BASF PLANT SCIENCE COMPANY GMBH (DE) | 2011-04-28 | — | — | WO | disclosed |
| US-20110039721-A1 | METHOD FOR PREDICTION ABOUT CARCINOGENICITY OF SUBSTANCE IN RODENT | CHEMICALS EVALUATION AND RESEARCH INSTITUTE (JP) | 2011-02-17 | — | — | US | disclosed |
| EP-2098226-A1 | AKAP-PKA interaction inhibitors for use in the treatment of heart diseases | Forschungsverbund Berlin e.V. (DE) | 2009-09-09 | — | — | EP | disclosed |
| US-7091033-B2 | Monitoring preferential gene expression profile; obtain cellsample, incubate with modulator, monitor gene expression profile, compare to control, evaluate gene expression | PHASE-1 MOLECULAR TOXICOLOGY, INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20030165854-A1 | Marker genes responding to treatment with toxins | INCYTE GENOMICS, INC. | 2003-09-04 | — | — | US | disclosed |
| EP-1235933-A2 | MAMMALIAN TOXICOLOGICAL RESPONSE MARKERS | Incyte Genomics, Inc. (US) | 2002-09-04 | — | — | EP | disclosed |
| US-6372431-B1 | TREATING A MAMMALIAN SUBJECT WITH TOXIC COMPOUND OR MOLECULE; OBTAINING A SAMPLE CONTAINING NUCLEIC ACIDS FROM MAMMAL TREATED WITH TOXIC COMPOUND OR MOLECULE; CONTACTING SAMPLE WITH MICROARRAY; DETECTING HYBRIDIZATION COMPLEXES | INCYTE GENOMICS, INC. | 2002-04-16 | — | — | US | disclosed |
| WO-2001036684-A2 | MAMMALIAN TOXICOLOGICAL RESPONSE MARKERS | INCYTE GENOMICS, INC. (US) | 2001-05-25 | — | — | WO | disclosed |