Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 4/20 | 0.45 |
| ▸ | BLM | P54132 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742705 | 1.00 | THRB (0.45) | THRBKMT2ALMNAMEN1HSD17B10 | |
| SCHEMBL11742941 | 0.91 | THRB (0.42) | THRBKMT2ALMNAMEN1HSD17B10 | |
| SCHEMBL169323 | 0.90 | LMNA (0.54) | THRBKMT2ALMNAMEN1HSD17B10 | |
| SCHEMBL5319562 | 0.90 | LMNA (0.54) | THRBKMT2ALMNAMEN1HSD17B10 | |
| SCHEMBL4926007 | 0.90 | THRB (0.41) | THRBKMT2ALMNAMEN1HSD17B10 | |
| SCHEMBL6694580 | 0.89 | SCN9A (0.37) | THRBKMT2ALMNAMEN1HSD17B10 | |
| SCHEMBL16671244 | 0.88 | PTPRA (0.38) | THRBKMT2ALMNAMEN1HSD17B10 | |
| SCHEMBL230513 | 0.84 | KMT2A (0.52) | THRBKMT2ALMNAMEN1HSD17B10 | |
| SCHEMBL5574192 | 0.84 | KMT2A (0.52) | THRBKMT2ALMNAMEN1HSD17B10 | |
| SCHEMBL282065 | 0.84 | KMT2A (0.52) | THRBKMT2ALMNAMEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190748-A1 | GREATER UTILITY WITH THYROID HORMONE | TREASURER HAREN (CA) | 2012-07-26 | — | — | US | claimed |
| EP-2461804-A2 | GREATER UTILITY WITH THYROID HORMONE | Treasurer, Haren (CA) | 2012-06-13 | — | — | EP | claimed |
| WO-2011015953-A2 | GREATER UTILITY WITH THYROID HORMONE | TREASURER HAREN (CA) | 2011-02-10 | — | — | WO | claimed |
| CN-112300133-B | Heterocyclic compound and application thereof | 深圳微芯生物科技股份有限公司 | 2024-07-30 | — | — | CN | disclosed |
| CN-111909137-B | Pyridazinone derivative and application thereof | 深圳微芯生物科技股份有限公司 | 2023-05-30 | — | — | CN | disclosed |
| CN-114846001-A | Benzo-fused ring compounds | 南京明德新药研发有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-114634486-A | Thyroxine receptor beta selective agonist compounds, pharmaceutical compositions and uses thereof | 中国科学院上海药物研究所 | 2022-06-17 | — | — | CN | disclosed |
| CN-112645936-B | Substituted pyridazinone compound and use thereof | 山东第一医科大学(山东省医学科学院) | 2022-03-01 | — | — | CN | disclosed |
| EP-3955954-A1 | COMBINATION THERAPY FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES | NGM Biopharmaceuticals, Inc. (US) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020214753-A1 | COMBINATION THERAPY FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES | NGM BIOPHARMACEUTICALS, INC. (US) | 2020-10-22 | — | — | WO | disclosed |
| EP-3390633-A1 | KINASE AND UBIQUITIN LIGASE INHIBITORS AND USES THEREOF | Alda S.r.L. (IT) | 2018-10-24 | — | — | EP | disclosed |
| EP-1565171-A2 | CONTROLLED ABSORPTION OF MIXED THYROYD HORMONE FORMULATIONS | New River Pharmaceuticals Inc. (US) | 2005-08-24 | — | — | EP | disclosed |
| EP-1012329-A4 | DIAGNOSIS AND TREATMENT OF MYOCARDIAL FAILURE | UNIV TECHNOLOGY CORP (US) | 2004-08-11 | — | — | EP | disclosed |
| US-20040152783-A1 | Controlled absorption of admixed thyroid hormone formulations | SHIRE LLC | 2004-08-05 | — | — | US | disclosed |
| WO-2004041208-A2 | CONTROLLED ABSORPTION OF MIXED THYROYD HORMONE FORMULATIONS | NEW RIVER PHARMACEUTICALS INC. (US) | 2004-05-21 | — | — | WO | disclosed |
| EP-1262177-A2 | Medical use of thyromimetic compounds to treat hair loss and compositions | Pfizer Products Inc. (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-1012329-A1 | DIAGNOSIS AND TREATMENT OF MYOCARDIAL FAILURE | University Technology Corporation (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1999043307-A1 | THYROID HORMONE REPLACEMENT USING SUSTAINED RELEASE TRIIODOTHYRONINE | PRANGE ARTHUR J JR (US) | 1999-09-02 | — | — | WO | disclosed |
| WO-1998033942-A1 | DIAGNOSIS AND TREATMENT OF MYOCARDIAL FAILURE | UNIVERSITY TECHNOLOGY CORPORATION (US) | 1998-08-06 | — | — | WO | disclosed |
| WO-1991006569-A1 | IODOTHYRONINE POLYMERS | BOOTS PHARMACEUTICALS INC. (US) | 1991-05-16 | — | — | WO | disclosed |