Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430640 | 0.84 | ALDH1A1 (0.53) | ALDH1A1CYP1A2CYP1A1CYP1B1TAS1R3 | |
| SCHEMBL1223114 | 0.80 | PTGS2 (0.37) | ALDH1A1TAS1R3TAS1R1TAS1R2PTGS2 | |
| SCHEMBL25425757 | 0.80 | TAAR1 (0.45) | TAAR1ALDH1A1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL19088270 | 0.80 | KMT2A (0.41) | ALDH1A1CYP1A2PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL31015937 | 0.80 | PTGS2 (0.37) | ALDH1A1TAS1R3TAS1R1TAS1R2PTGS2 | |
| SCHEMBL12216295 | 0.78 | ACHE (0.43) | ALDH1A1TAS1R3TAS1R1TAS1R2PTGS2 | |
| SCHEMBL15334771 | 0.78 | TAAR1 (0.44) | TAAR1ALDH1A1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL19922066 | 0.77 | PTGS2 (0.42) | ALDH1A1CYP1A2PTGS2MAPTNPC1 | |
| SCHEMBL15271622 | 0.77 | ACLY (0.41) | ALDH1A1PTGS2MAPTTPMTKDM4E | |
| SCHEMBL12745843 | 0.77 | TDP1 (0.46) | ALDH1A1TAS1R3TAS1R1TAS1R2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071150-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | ALAM MUZAFFAR | 2011-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071150-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | ORAI1, RYR2, CACNA1E | TAAR1 187/4885ALDH1A1 1801/4885CYP1A2 1233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.