Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 7/20 | 0.47 |
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | CA12 | O43570 | 6/20 | 0.47 |
| ▸ | CA9 | Q16790 | 6/20 | 0.47 |
| ▸ | STK17B | O94768 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28230787 | 0.84 | MEN1 (0.62) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL569251 | 0.84 | TDP1 (0.74) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL15597154 | 0.83 | MEN1 (0.60) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL16197667 | 0.83 | MEN1 (0.60) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL2402827 | 0.82 | MEN1 (0.64) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL31606661 | 0.81 | MEN1 (0.62) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL6938487 | 0.80 | MEN1 (0.66) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL3020258 | 0.80 | TDP1 (0.81) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL25353243 | 0.80 | MEN1 (0.69) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL18489848 | 0.80 | MEN1 (0.60) | MEN1GAAKMT2ATDP1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828386-B1 | AMIDE AND PEPTIDE DERIVATIVES OF DIALKYLENETRIAMINES AND THEIR USE AS TRANSFECTION AGENTS | GLAXO GROUP LTD (GB) | 2012-08-08 | — | — | EP | disclosed |
| US-20110045027-A1 | Adjuvant | GLAXO GROUP LIMITED (GB) | 2011-02-24 | — | — | US | disclosed |
| US-7759519-B2 | Amide and peptide derivatives of dialkylenetriamines and their use as transfection agents | GLAXO GROUP LIMITED (GB) | 2010-07-20 | — | — | US | disclosed |
| US-20090209472-A1 | AMIDE AND PEPTIDE DERIVATIVES OF DIALKYLENETRIAMINES AND THEIR USE AS TRANSFECTION AGENTS | GLAXO GROUP LIMITED (GB) | 2009-08-20 | — | — | US | disclosed |
| EP-1828386-A1 | AMIDE AND PEPTIDE DERIVATIVES OF DIALKYLENETRIAMINES AND THEIR USE AS TRANSFECTION AGENTS | GLAXO GROUP LIMITED (GB) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006053782-A1 | AMIDE AND PEPTIDE DERIVATIVES OF DIALKYLENETRIAMINES AND THEIR USE AS TRANSFECTION AGENTS | GLAXO GROUP LIMITED (GB) | 2006-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110045027-A1 | Adjuvant | TLR3, TLR9, TLR7 | MEN1 4058/4885GAA 2836/4885KMT2A 3326/4885 |
| US-20090209472-A1 | AMIDE AND PEPTIDE DERIVATIVES OF DIALKYLENETRIAMINES AND THEIR USE AS TRANSFECTION AGENTS | SRM, SMS, DLST | MEN1 736/4885GAA 2329/4885KMT2A 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.